Gene Page: CFTR

Summary
GeneID  1080
Symbol  CFTR
Synonyms  ABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1
Description  cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
See related  HGNC:1884|MIM:602421|Ensembl:ENSG00000001626|HPRD:03883|
Locus tag  tcag7.78
Gene type  protein-coding
Map location  7q31.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.469 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0352 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI11707463 |15247260 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingTAS2475911 
GO:0005254chloride channel activityIEA-
GO:0005260channel-conductance-controlling ATPase activityNAS11707463 
GO:0005216ion channel activityIEA-
GO:0005224ATP-binding and phosphorylation-dependent chloride channel activityTAS10581360 
GO:0030165PDZ domain bindingIDA11707463 
GO:0016887ATPase activityIEA-
GO:0031404chloride ion bindingIEA-
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007585respiratory gaseous exchangeTAS9875854 
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016323basolateral plasma membraneNAS11707463 
GO:0016324apical plasma membraneIDA15247260 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CANXCNX | FLJ26570 | IP90 | P90calnexinCFTR interacts with CANX. This interaction was modeled on a demonstrated interaction between human CFTR and hamster CANX.BIND15105504 
CFTR interacts with CANX.BIND7513695 
CFTRABC35 | ABCC7 | CF | CFTR/MRP | MRP7 | TNR-CFTR | dJ760C5.1cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)-HPRD,BioGRID11051556 
CFTR forms a homodimerBIND12933354 
CLCN3CLC3 | ClC-3chloride channel 3Reconstituted ComplexBioGRID12471024 
DNAJA1DJ-2 | DjA1 | HDJ2 | HSDJ | HSJ2 | HSPF4 | hDJ-2DnaJ (Hsp40) homolog, subfamily A, member 1-HPRD,BioGRID10075921 
DNAJB1HSPF1 | Hdj1 | Hsp40 | Sis1DnaJ (Hsp40) homolog, subfamily B, member 1Affinity Capture-WesternBioGRID10075921 
DNAJC5CSP | DKFZp434N1429 | DKFZp761N1221 | DNAJC5A | FLJ00118 | FLJ13070DnaJ (Hsp40) homolog, subfamily C, member 5Csp1 interacts with CFTR.BIND12039948 
in vitroBioGRID12039948 
Csp2 interacts with CFTR.BIND12039948 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD,BioGRID10893422 
GOPCCAL | FIG | GOPC1 | PIST | dJ94G16.2golgi associated PDZ and coiled-coil motif containing-HPRD,BioGRID11707463 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8Affinity Capture-WesternBioGRID10075921 
KCNJ1KIR1.1 | ROMK | ROMK1potassium inwardly-rectifying channel, subfamily J, member 1Affinity Capture-WesternBioGRID14604981 
PDZD3FLJ22756 | IKEPP | PDZK2PDZ domain containing 3Reconstituted ComplexBioGRID12615054 
PDZK1CAP70 | CLAMP | NHERF3 | PDZD1PDZ domain containing 1-HPRD,BioGRID11051556 |12471024 
|12615054 
PRKAA1AMPK | AMPKa1 | MGC33776 | MGC57364protein kinase, AMP-activated, alpha 1 catalytic subunit-HPRD,BioGRID10862786 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alphaPKA II interacts with and phosphorylates CFTR.BIND10799517 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilon-HPRD,BioGRID11956211 
SLC4A7DKFZp686H168 | NBC2 | NBC3 | SBC2 | SLC4A6solute carrier family 4, sodium bicarbonate cotransporter, member 7-HPRD,BioGRID12403779 
SLC4A8DKFZp761B2318 | FLJ46462 | NBC3solute carrier family 4, sodium bicarbonate cotransporter, member 8-HPRD,BioGRID12403779 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1First PDZ domain of EBP50 binds to the C-terminus of CFTR.BIND9671706 |9677412 
|10852925 |12621035 
-HPRD9613608 |9677412 
|10852925 
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID9613608 |9671706 
|9677412 |10852925 
|12471024 |12615054 
SLC9A3R2E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2-HPRD,BioGRID9671706 |10893422 
The second PDZ domain of E3KARP interacts with the C-terminal PDZ binding motif of CFTR.BIND10893422 
SLC9A6KIAA0267 | MRSA | NHE6solute carrier family 9 (sodium/hydrogen exchanger), member 6in vivoBioGRID11707463 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDa-HPRD,BioGRID12209004 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Syntaxin 1A interacts with CFTR.BIND9384384 |12446681 
-HPRD,BioGRID9384384 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ABC_TRANSPORTERS 4429All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION 5632All SZGR genes in this pathway
BIOCARTA_CFTR_PATHWAY 1211All SZGR genes in this pathway
REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT 3421All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP 10867All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_DN 8142All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_DN 13870All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER 5538All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
WAGSCHAL_EHMT2_TARGETS_UP 137All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101150815141Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-144150815141Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-37715491555m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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