Gene Page: SRCAP

Summary
GeneID  10847
Symbol  SRCAP
Synonyms  DOMO1|EAF1|FLJ44499|KIAA0309|SWR1
Description  Snf2-related CREBBP activator protein
See related  HGNC:16974|MIM:611421|Ensembl:ENSG00000080603|HPRD:18103|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RGS60.450.43
LRRTM40.440.44
PDE1A0.440.43
GALNT130.430.36
KCNJ60.430.38
BRAF0.420.43
SH3GL20.420.42
DOK60.420.40
C6orf1420.420.43
ITGA110.420.42
Top 10 negatively co-expressed genes
VEGFB-0.35-0.32
RHOC-0.34-0.40
EFEMP2-0.33-0.28
RAB34-0.30-0.32
GATSL3-0.30-0.31
C19orf36-0.29-0.30
SERPINB6-0.29-0.33
S100A16-0.28-0.34
SLC2A4RG-0.28-0.30
NUDT8-0.28-0.27
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIEA-
GO:0003713transcription coactivator activityTAS10347196 
GO:0005524ATP bindingIEA-
GO:0004386helicase activityIEA-
GO:0004402histone acetyltransferase activityTAS10347196 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS10347196 
GO:0006350transcriptionIEA-
GO:0016568chromatin modificationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CARM1PRMT4coactivator-associated arginine methyltransferase 1-HPRD14500758 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD10347196 |11581372 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD11581372 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2-HPRD14500758 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Co-purificationBioGRID11013263 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
FOURNIER_ACINAR_DEVELOPMENT_EARLY_UP 2119All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ZUCCHI_METASTASIS_UP 4324All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_UP 3930All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 7645All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a2172241A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-2674811A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-324-3p215221m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-491246252m8hsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
miR-9135141m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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