Gene Page: CYP46A1

Summary
GeneID  10858
Symbol  CYP46A1
Synonyms  CP46|CYP46
Description  cytochrome P450, family 46, subfamily A, polypeptide 1
See related  HGNC:2641|MIM:604087|Ensembl:ENSG00000036530|HPRD:04970|
Locus tag  -
Gene type  protein-coding
Map location  14q32.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SP10.870.88
CTDSP20.850.84
EIF2C10.840.86
SS180.840.84
EIF2C30.830.83
CRTC30.830.84
ARNT0.820.82
GPATCH80.820.83
H6PD0.810.79
NUP980.810.80
Top 10 negatively co-expressed genes
AF347015.21-0.60-0.67
AF347015.31-0.56-0.60
MT-CO2-0.56-0.60
IL32-0.55-0.66
IFI27-0.55-0.58
C1orf54-0.54-0.64
HIGD1B-0.53-0.57
CXCL14-0.52-0.57
AF347015.8-0.51-0.55
AF347015.27-0.50-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0004497monooxygenase activityIEA-
GO:0020037heme bindingIEA-
GO:0008395steroid hydroxylase activityTAS10377398 
GO:0009055electron carrier activityIEA-
GO:0033781cholesterol 24-hydroxylase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)10377398 
GO:0008202steroid metabolic processIEA-
GO:0006707cholesterol catabolic processTAS10377398 
GO:0006629lipid metabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumTAS10377398 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS 169All SZGR genes in this pathway
REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM 2711All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL 106All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS 199All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE 5134All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
REACTOME_ENDOGENOUS_STEROLS 1510All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98397403m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-505563569m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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