Gene Page: TLK2

Summary
GeneID  11011
Symbol  TLK2
Synonyms  MGC44450|PKU-ALPHA
Description  tousled-like kinase 2
See related  HGNC:11842|MIM:608439|Ensembl:ENSG00000146872|HPRD:10527|
Locus tag  -
Gene type  protein-coding
Map location  17q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0673 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ALDH1L10.910.90
METTL7A0.860.90
MERTK0.860.90
RANBP3L0.850.88
ALDH6A10.850.89
MRO0.850.87
HTRA10.850.91
NDRG20.840.88
ALDH20.840.84
CYP4F110.840.85
Top 10 negatively co-expressed genes
PHF14-0.58-0.70
MLLT11-0.57-0.65
PPP3CC-0.57-0.68
DPF1-0.57-0.65
MED19-0.57-0.70
RNF19B-0.57-0.67
FAM40A-0.57-0.63
STMN2-0.57-0.68
MPP3-0.56-0.64
RTF1-0.56-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIDA12660173 
GO:0004674protein serine/threonine kinase activityIDA12660173 
GO:0004674protein serine/threonine kinase activityNAS9427565 |10523312 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001672regulation of chromatin assembly or disassemblyIDA12660173 
GO:0006468protein amino acid phosphorylationIDA12660173 
GO:0007242intracellular signaling cascadeIDA12660173 
GO:0007049cell cycleIEA-
GO:0006974response to DNA damage stimulusIEA-
GO:0016568chromatin modificationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA9427565 
GO:0005634nucleusNAS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASF1ACGI-98 | CIA | DKFZp547E2110 | HSPC146ASF1 anti-silencing function 1 homolog A (S. cerevisiae)-HPRD,BioGRID11470414 
ASF1BCIA-II | FLJ10604ASF1 anti-silencing function 1 homolog B (S. cerevisiae)-HPRD,BioGRID11470414 
MBPMGC99675myelin basic protein-HPRD10523312 
TLK1KIAA0137 | PKU-betatousled-like kinase 1-HPRD,BioGRID10523312 
TLK2MGC44450 | PKU-ALPHAtousled-like kinase 2-HPRD10523312 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
HEIDENBLAD_AMPLIFIED_IN_PANCREATIC_CANCER 3119All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PARK_HSC_MARKERS 4431All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN 12386All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D5 3926All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
CHENG_RESPONSE_TO_NICKEL_ACETATE 4529All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
WENDT_COHESIN_TARGETS_UP 3319All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101300306m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-125/351326332m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-1283023081Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-217921927m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-2184634691Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-22185191m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-263693751Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-273023091A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-320681687m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3842062121Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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