Gene Page: NUDT21

Summary
GeneID  11051
Symbol  NUDT21
Synonyms  CFIM25|CPSF5|DKFZp686H1588
Description  nudix (nucleoside diphosphate linked moiety X)-type motif 21
See related  HGNC:13870|MIM:604978|Ensembl:ENSG00000167005|HPRD:05400|
Locus tag  -
Gene type  protein-coding
Map location  16q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0813 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NAGS0.950.23
ZIC40.940.57
ZIC20.930.64
ZIC10.920.64
PROX10.910.40
GBX20.880.26
KITLG0.880.20
CD2470.870.20
KRT18P190.860.07
LHX90.850.14
Top 10 negatively co-expressed genes
SLC26A4-0.17-0.20
C11orf51-0.16-0.38
GTDC1-0.16-0.14
MTIF3-0.15-0.40
KIAA1614-0.150.08
C20orf39-0.140.09
GRIA3-0.14-0.00
CRYM-0.14-0.20
THYN1-0.14-0.22
CACNG3-0.130.01
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingIDA8626397 
GO:0005515protein bindingIPI11716503 |14561889 |15169763 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA11256614 
GO:0005634nucleusIEA-
GO:0042382paraspecklesIDA15169763 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2Affinity Capture-MSBioGRID17353931 
CPSF6CFIM | CFIM68 | HPBRII-4 | HPBRII-7cleavage and polyadenylation specific factor 6, 68kDaTwo-hybridBioGRID16189514 
EXOSC6EAP4 | MTR3 | Mtr3p | hMtr3p | p11exosome component 6-HPRD,BioGRID15231747 
FLJ12529FLJ39024 | MGC9315pre-mRNA cleavage factor I, 59 kDa subunitTwo-hybridBioGRID16189514 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
MYL6ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SMmyosin, light chain 6, alkali, smooth muscle and non-muscleTwo-hybridBioGRID16189514 
NIF3L1ALS2CR1 | CALS-7 | MDS015NIF3 NGG1 interacting factor 3-like 1 (S. pombe)Two-hybridBioGRID16189514 
NUDT21CFIM25 | CPSF5 | DKFZp686H1588nudix (nucleoside diphosphate linked moiety X)-type motif 21Two-hybridBioGRID16189514 
PSMF1PI31proteasome (prosome, macropain) inhibitor subunit 1 (PI31)Two-hybridBioGRID16189514 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
RPLP1FLJ27448 | MGC5215 | P1 | RPP1ribosomal protein, large, P1Two-hybridBioGRID16169070 
SNRNP70RNPU1Z | RPU1 | SNRP70 | U170K | U1AP | U1RNPsmall nuclear ribonucleoprotein 70kDa (U1)Reconstituted ComplexBioGRID14561889 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 146All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 2310All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_MRNA_3_END_PROCESSING 3518All SZGR genes in this pathway
REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 4422All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP 8951All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_UP 8847All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
MELLMAN_TUT1_TARGETS_DN 4729All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12 7954All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_5_DN 5031All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2 7337All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway


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