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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: CIT

Summary

GeneID

11113

Symbol

CIT

Synonyms

CRIK|KIAA0949|STK21

Description

citron (rho-interacting, serine/threonine kinase 21)

Locus tag

Gene type

protein-coding

Map location

12q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1678

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

IFI44L

0.82

0.68

PARP9

0.81

0.71

PLSCR1

0.79

0.62

TAP1

0.79

0.59

IRF9

0.75

0.57

IFIT3

0.74

0.55

OAS1

0.72

0.49

IFIT1

0.71

0.50

HERC5

0.71

0.66

IFITM3

0.71

0.42

Top 10 negatively co-expressed genes

LMO7

-0.35

MYT1L

-0.35

-0.32

MEF2C

-0.34

-0.35

DPP4

-0.34

-0.37

MPPED1

-0.34

-0.36

AC079953.2

-0.34

-0.32

SATB2

-0.34

-0.39

LRFN2

-0.34

-0.33

SPTAN1

-0.34

-0.30

KLHL1

-0.34

-0.31

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005083

small GTPase regulator activity

IEA

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

ISS

9792683

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0017124

SH3 domain binding

IEA

GO:0019992

diacylglycerol binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0048699

generation of neurons

ISS

neuron, neurogenesis (GO term level: 7)

11086988

GO:0007399

nervous system development

IEA

neurite (GO term level: 5)

GO:0006468

protein amino acid phosphorylation

IEA

GO:0007242

intracellular signaling cascade

IEA

GO:0007049

cell cycle

IEA

GO:0007067

mitosis

ISS

11086988

GO:0008152

metabolic process

IEA

GO:0007275

multicellular organismal development

IEA

GO:0030154

cell differentiation

IEA

GO:0051301

cell division

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
DISC1	C1orf136 \| FLJ13381 \| FLJ21640 \| FLJ25311 \| FLJ41105 \| KIAA0457 \| SCZD9	disrupted in schizophrenia 1	Two-hybrid	BioGRID	12506198
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	in vivo Two-hybrid	BioGRID	9870942
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Far Western	BioGRID	8543060
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Far Western Reconstituted Complex Two-hybrid	BioGRID	8543060 \|12773565
RHOB	ARH6 \| ARHB \| MST081 \| MSTP081 \| RHOH6	ras homolog gene family, member B	Far Western Two-hybrid	BioGRID	8543060
RHOC	ARH9 \| ARHC \| H9 \| MGC1448 \| MGC61427 \| RHOH9	ras homolog gene family, member C	Two-hybrid	BioGRID	8543060
RND3	ARHE \| Rho8 \| RhoE \| memB	Rho family GTPase 3	Two-hybrid	BioGRID	12773565

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_RHOA_PATHWAY	45	33	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP	633	376	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN	378	231	All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE	217	143	All SZGR genes in this pathway
INAMURA_LUNG_CANCER_SCC_SUBTYPES_UP	14	9	All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5	94	59	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215	893	528	All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN	163	115	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP	83	66	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN	298	200	All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN	142	94	All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED	728	415	All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP	180	114	All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP	250	168	All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_UP	93	56	All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP	163	102	All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_DN	10	10	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN	254	158	All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M	216	124	All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP	324	193	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	570	339	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	1280	1286	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1280	1286	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-138	698	704	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-140	1177	1183	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-142-5p	2074	2081	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-148/152	1119	1125	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-181	708	714	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-221/222	1115	1121	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1115	1121	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-224	1283	1289	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367	852	858	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	1280	1286	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1280	1286	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	651	657	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-324-3p	742	749	1A,m8	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-326	1159	1165	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-328	754	760	1A	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-370	2234	2241	1A,m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-500	1390	1396	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-500	1390	1396	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.