Gene Page: CHRNA3

Summary
GeneID  1136
Symbol  CHRNA3
Synonyms  LNCR2|MGC104879|PAOD2
Description  cholinergic receptor, nicotinic, alpha 3
See related  HGNC:1957|MIM:118503|Ensembl:ENSG00000080644|HPRD:07511|
Locus tag  -
Gene type  protein-coding
Map location  15q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 16 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0015464acetylcholine receptor activityIDANeurotransmitter (GO term level: 6)8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIDA8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060084synaptic transmission involved in micturitionIEAneuron, Synap (GO term level: 8)-
GO:0060084synaptic transmission involved in micturitionIMPneuron, Synap (GO term level: 8)11450844 
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0060079regulation of excitatory postsynaptic membrane potentialISSneuron, Synap (GO term level: 10)-
GO:0007271synaptic transmission, cholinergicIEAneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)-
GO:0007271synaptic transmission, cholinergicISSneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)-
GO:0014056regulation of acetylcholine secretionIEANeurotransmitter (GO term level: 10)-
GO:0014056regulation of acetylcholine secretionISSNeurotransmitter (GO term level: 10)-
GO:0048814regulation of dendrite morphogenesisIEAdendrite (GO term level: 13)-
GO:0048814regulation of dendrite morphogenesisISSdendrite (GO term level: 13)-
GO:0007399nervous system developmentIMPneurite (GO term level: 5)11450844 
GO:0007165signal transductionIDA8906617 
GO:0007626locomotory behaviorIEA-
GO:0007626locomotory behaviorISS-
GO:0006811ion transportIEA-
GO:0006811ion transportNAS8906617 
GO:0006940regulation of smooth muscle contractionIEA-
GO:0006940regulation of smooth muscle contractionISS-
GO:0007171activation of transmembrane receptor protein tyrosine kinase activityIEA-
GO:0007171activation of transmembrane receptor protein tyrosine kinase activityISS-
GO:0042391regulation of membrane potentialIEA-
GO:0042391regulation of membrane potentialISS-
GO:0035095behavioral response to nicotineIEA-
GO:0035095behavioral response to nicotineIMP18227835 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIDANeurotransmitter (GO term level: 9)8906617 
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIEANeurotransmitter (GO term level: 9)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS8906617 
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CHRNB4-cholinergic receptor, nicotinic, beta 4-HPRD,BioGRID1689727 |1725184 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 1613All SZGR genes in this pathway
REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 1312All SZGR genes in this pathway
REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 1210All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_DN 5735All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
KANG_GIST_WITH_PDGFRA_UP 5027All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_UP 3922All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway


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