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GeneID |
1139
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Symbol |
CHRNA7
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Synonyms |
CHRNA7-2|NACHRA7
|
Description |
cholinergic receptor, nicotinic, alpha 7 |
See related |
HGNC:1960|MIM:118511|Ensembl:ENSG00000175344|HPRD:00339| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
15q14 |
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Gene set name |
Method of gene set |
Evidence |
Info |
Association | A combined odds ratio method (Sun et al. 2008), association studies | 2 | Link to SZGene | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 6 | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
|
Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
KIAA0196 | 0.87 | 0.85 | | |
TRIP12 | 0.87 | 0.87 | | |
MTMR15 | 0.86 | 0.86 | | |
IPO8 | 0.86 | 0.85 | | |
KIAA1012 | 0.85 | 0.86 | | |
FAM178A | 0.85 | 0.86 | | |
NBR1 | 0.85 | 0.84 | | |
PTK2 | 0.85 | 0.83 | | |
UTP14C | 0.84 | 0.86 | | |
RBBP5 | 0.84 | 0.85 | | |
Top 10 negatively co-expressed genes | AF347015.21 | -0.67 | -0.64 | | |
IFI27 | -0.64 | -0.67 | | |
IL32 | -0.62 | -0.61 | | |
MT-CO2 | -0.62 | -0.62 | | |
FXYD1 | -0.61 | -0.63 | | |
HIGD1B | -0.60 | -0.63 | | |
VAMP5 | -0.60 | -0.60 | | |
AF347015.31 | -0.59 | -0.62 | | |
CXCL14 | -0.59 | -0.63 | | |
CSAG1 | -0.59 | -0.59 | | |
|
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0030594 | neurotransmitter receptor activity | IEA | Neurotransmitter (GO term level: 5) | - |
GO:0015464 | acetylcholine receptor activity | IDA | Neurotransmitter (GO term level: 6) | 8906617 |
GO:0001540 | beta-amyloid binding | IPI | | 10681545 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IDA | | 8145738 |8906617 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IEA | | - |
GO:0005515 | protein binding | IEA | | - |
GO:0005216 | ion channel activity | IEA | | - |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | | - |
GO:0015643 | toxin binding | IDA | | 12508119 |
GO:0017081 | chloride channel regulator activity | IDA | | 8145738 |
GO:0042803 | protein homodimerization activity | IDA | | 8145738 |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007271 | synaptic transmission, cholinergic | IEA | neuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7) | - |
GO:0032225 | regulation of synaptic transmission, dopaminergic | IEA | neuron, Synap, Neurotransmitter, dopamine (GO term level: 9) | - |
GO:0000187 | activation of MAPK activity | IDA | | 10771023 |
GO:0001666 | response to hypoxia | IDA | | 12189247 |
GO:0001988 | positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure | IEA | | - |
GO:0007165 | signal transduction | IDA | | 8906617 |
GO:0008284 | positive regulation of cell proliferation | IMP | | 16280133 |17498763 |
GO:0008306 | associative learning | IEA | | - |
GO:0007613 | memory | IEA | | - |
GO:0007613 | memory | NAS | | 10681545 |
GO:0006816 | calcium ion transport | IDA | | 8145738 |
GO:0006816 | calcium ion transport | IMP | | 10771023 |
GO:0006811 | ion transport | IEA | | - |
GO:0006811 | ion transport | NAS | | 8906617 |
GO:0006897 | endocytosis | IEA | | - |
GO:0006874 | cellular calcium ion homeostasis | IMP | | 16280133 |
GO:0014061 | regulation of norepinephrine secretion | IEA | | - |
GO:0042391 | regulation of membrane potential | IEA | | - |
GO:0032094 | response to food | IEA | | - |
GO:0042698 | ovulation cycle | IEA | | - |
GO:0042113 | B cell activation | IEA | | - |
GO:0042110 | T cell activation | IEA | | - |
GO:0032720 | negative regulation of tumor necrosis factor production | IEA | | - |
GO:0032720 | negative regulation of tumor necrosis factor production | IMP | | 12508119 |
GO:0032715 | negative regulation of interleukin-6 production | IEA | | - |
GO:0032691 | negative regulation of interleukin-1 beta production | IEA | | - |
GO:0030317 | sperm motility | IEA | | - |
GO:0035095 | behavioral response to nicotine | IEA | | - |
GO:0045766 | positive regulation of angiogenesis | IMP | | 12189247 |16280133 |
GO:0048149 | behavioral response to ethanol | IEA | | - |
GO:0050728 | negative regulation of inflammatory response | IDA | | 12508119 |
GO:0050728 | negative regulation of inflammatory response | IEA | | - |
GO:0060112 | generation of ovulation cycle rhythm | IEA | | - |
GO:0050890 | cognition | IMP | | 16754836 |
GO:0050890 | cognition | NAS | | 10681545 |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | IDA | Neurotransmitter (GO term level: 9) | 8906617 |
GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
GO:0005624 | membrane fraction | IEA | | - |
GO:0016021 | integral to membrane | IEA | | - |
GO:0016021 | integral to membrane | NAS | | 8145738 |8906617 |
GO:0009897 | external side of plasma membrane | IEA | | - |
GO:0005886 | plasma membrane | IDA | | 16280133 |
GO:0016324 | apical plasma membrane | IEA | | - |
GO:0030054 | cell junction | IEA | | - |
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