Gene Page: CHRNA7

Summary
GeneID  1139
Symbol  CHRNA7
Synonyms  CHRNA7-2|NACHRA7
Description  cholinergic receptor, nicotinic, alpha 7
See related  HGNC:1960|MIM:118511|Ensembl:ENSG00000175344|HPRD:00339|
Locus tag  -
Gene type  protein-coding
Map location  15q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA01960.870.85
TRIP120.870.87
MTMR150.860.86
IPO80.860.85
KIAA10120.850.86
FAM178A0.850.86
NBR10.850.84
PTK20.850.83
UTP14C0.840.86
RBBP50.840.85
Top 10 negatively co-expressed genes
AF347015.21-0.67-0.64
IFI27-0.64-0.67
IL32-0.62-0.61
MT-CO2-0.62-0.62
FXYD1-0.61-0.63
HIGD1B-0.60-0.63
VAMP5-0.60-0.60
AF347015.31-0.59-0.62
CXCL14-0.59-0.63
CSAG1-0.59-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0015464acetylcholine receptor activityIDANeurotransmitter (GO term level: 6)8906617 
GO:0001540beta-amyloid bindingIPI10681545 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIDA8145738 |8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIEA-
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0015643toxin bindingIDA12508119 
GO:0017081chloride channel regulator activityIDA8145738 
GO:0042803protein homodimerization activityIDA8145738 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007271synaptic transmission, cholinergicIEAneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)-
GO:0032225regulation of synaptic transmission, dopaminergicIEAneuron, Synap, Neurotransmitter, dopamine (GO term level: 9)-
GO:0000187activation of MAPK activityIDA10771023 
GO:0001666response to hypoxiaIDA12189247 
GO:0001988positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressureIEA-
GO:0007165signal transductionIDA8906617 
GO:0008284positive regulation of cell proliferationIMP16280133 |17498763 
GO:0008306associative learningIEA-
GO:0007613memoryIEA-
GO:0007613memoryNAS10681545 
GO:0006816calcium ion transportIDA8145738 
GO:0006816calcium ion transportIMP10771023 
GO:0006811ion transportIEA-
GO:0006811ion transportNAS8906617 
GO:0006897endocytosisIEA-
GO:0006874cellular calcium ion homeostasisIMP16280133 
GO:0014061regulation of norepinephrine secretionIEA-
GO:0042391regulation of membrane potentialIEA-
GO:0032094response to foodIEA-
GO:0042698ovulation cycleIEA-
GO:0042113B cell activationIEA-
GO:0042110T cell activationIEA-
GO:0032720negative regulation of tumor necrosis factor productionIEA-
GO:0032720negative regulation of tumor necrosis factor productionIMP12508119 
GO:0032715negative regulation of interleukin-6 productionIEA-
GO:0032691negative regulation of interleukin-1 beta productionIEA-
GO:0030317sperm motilityIEA-
GO:0035095behavioral response to nicotineIEA-
GO:0045766positive regulation of angiogenesisIMP12189247 |16280133 
GO:0048149behavioral response to ethanolIEA-
GO:0050728negative regulation of inflammatory responseIDA12508119 
GO:0050728negative regulation of inflammatory responseIEA-
GO:0060112generation of ovulation cycle rhythmIEA-
GO:0050890cognitionIMP16754836 
GO:0050890cognitionNAS10681545 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIDANeurotransmitter (GO term level: 9)8906617 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005624membrane fractionIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS8145738 |8906617 
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIDA16280133 
GO:0016324apical plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADCY6AC6 | DKFZp779F075 | KIAA0422adenylate cyclase 6-HPRD,BioGRID12748066 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESAffinity Capture-WesternBioGRID11278378 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD11278378 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 1613All SZGR genes in this pathway
REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 1312All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway


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