Gene Page: CHRNB2

Summary
GeneID  1141
Symbol  CHRNB2
Synonyms  EFNL3|nAChRB2
Description  cholinergic receptor, nicotinic, beta 2 (neuronal)
See related  HGNC:1962|MIM:118507|Ensembl:ENSG00000160716|HPRD:00335|
Locus tag  -
Gene type  protein-coding
Map location  1q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 11 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SSBP30.730.75
SORCS10.700.71
KLHL320.700.67
NXPH30.690.62
EMX10.680.75
AC127496.30.650.64
TIAM20.650.69
HS3ST40.650.67
RGS60.630.66
RP1-21O18.10.630.66
Top 10 negatively co-expressed genes
CCDC80-0.48-0.61
RHOC-0.48-0.57
S100A16-0.46-0.55
TMEM51-0.46-0.54
BDH2-0.45-0.52
APOE-0.45-0.55
NMI-0.45-0.53
DBI-0.45-0.56
HSD17B14-0.45-0.51
SERPINB6-0.45-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0015464acetylcholine receptor activityIDANeurotransmitter (GO term level: 6)8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIDA8906617 
GO:0005515protein bindingISS-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060084synaptic transmission involved in micturitionISSneuron, Synap (GO term level: 8)-
GO:0051963regulation of synaptogenesisISSSynap (GO term level: 9)-
GO:0021631optic nerve morphogenesisISSBrain (GO term level: 9)-
GO:0032226positive regulation of synaptic transmission, dopaminergicIEAneuron, Synap, Neurotransmitter, dopamine (GO term level: 10)-
GO:0021952central nervous system projection neuron axonogenesisISSneuron, axon (GO term level: 14)-
GO:0033603positive regulation of dopamine secretionISSdopamine (GO term level: 11)-
GO:0042053regulation of dopamine metabolic processISSdopamine (GO term level: 9)-
GO:0048814regulation of dendrite morphogenesisISSdendrite (GO term level: 13)-
GO:0001666response to hypoxiaIDA12189247 
GO:0001661conditioned taste aversionIEA-
GO:0007165signal transductionIDA8906617 
GO:0008542visual learningIMP15964197 
GO:0007626locomotory behaviorISS-
GO:0007613memoryIMP15964197 
GO:0007605sensory perception of soundISS-
GO:0007601visual perceptionISS-
GO:0006816calcium ion transportISS-
GO:0006811ion transportNAS8906617 
GO:0006939smooth muscle contractionISS-
GO:0042220response to cocaineISS-
GO:0042320regulation of circadian sleep/wake cycle, REM sleepISS-
GO:0021562vestibulocochlear nerve developmentISS-
GO:0042113B cell activationISS-
GO:0030890positive regulation of B cell proliferationISS-
GO:0019233sensory perception of painISS-
GO:0021771lateral geniculate nucleus developmentISS-
GO:0035176social behaviorISS-
GO:0035095behavioral response to nicotineIMP17559419 
GO:0045759negative regulation of action potentialISS-
GO:0045188regulation of circadian sleep/wake cycle, non-REM sleepIEA-
GO:0045471response to ethanolISS-
GO:0050890cognitionIMP17559419 
GO:0051899membrane depolarizationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIDANeurotransmitter (GO term level: 9)8906617 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016021integral to membraneNAS8906617 
GO:0009897external side of plasma membraneISS-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CHRNA2-cholinergic receptor, nicotinic, alpha 2 (neuronal)-HPRD,BioGRID8906617 
CHRNA4BFNC | EBN | EBN1 | FLJ95812 | NACHR | NACHRA4 | NACRA4cholinergic receptor, nicotinic, alpha 4CHRNA4 (alpha-4) interacts with CHRNB2 (beta-2)BIND15944128 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 1613All SZGR genes in this pathway
REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 1312All SZGR genes in this pathway
REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 1210All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.