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GeneID |
1141
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Symbol |
CHRNB2
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Synonyms |
EFNL3|nAChRB2
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Description |
cholinergic receptor, nicotinic, beta 2 (neuronal) |
See related |
HGNC:1962|MIM:118507|Ensembl:ENSG00000160716|HPRD:00335| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
1q21.3 |
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Gene set name |
Method of gene set |
Evidence |
Info |
GSMA_I | genome scan meta-analysis | Psr: 0.0235 | | GSMA_IIA | genome scan meta-analysis (All samples) | Psr: 0.00814 | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 11 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
|
Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
SSBP3 | 0.73 | 0.75 | | |
SORCS1 | 0.70 | 0.71 | | |
KLHL32 | 0.70 | 0.67 | | |
NXPH3 | 0.69 | 0.62 | | |
EMX1 | 0.68 | 0.75 | | |
AC127496.3 | 0.65 | 0.64 | | |
TIAM2 | 0.65 | 0.69 | | |
HS3ST4 | 0.65 | 0.67 | | |
RGS6 | 0.63 | 0.66 | | |
RP1-21O18.1 | 0.63 | 0.66 | | |
Top 10 negatively co-expressed genes | CCDC80 | -0.48 | -0.61 | | |
RHOC | -0.48 | -0.57 | | |
S100A16 | -0.46 | -0.55 | | |
TMEM51 | -0.46 | -0.54 | | |
BDH2 | -0.45 | -0.52 | | |
APOE | -0.45 | -0.55 | | |
NMI | -0.45 | -0.53 | | |
DBI | -0.45 | -0.56 | | |
HSD17B14 | -0.45 | -0.51 | | |
SERPINB6 | -0.45 | -0.48 | | |
|
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0015464 | acetylcholine receptor activity | IDA | Neurotransmitter (GO term level: 6) | 8906617 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IDA | | 8906617 |
GO:0005515 | protein binding | ISS | | - |
GO:0005216 | ion channel activity | IEA | | - |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
---|
GO:0060084 | synaptic transmission involved in micturition | ISS | neuron, Synap (GO term level: 8) | - |
GO:0051963 | regulation of synaptogenesis | ISS | Synap (GO term level: 9) | - |
GO:0021631 | optic nerve morphogenesis | ISS | Brain (GO term level: 9) | - |
GO:0032226 | positive regulation of synaptic transmission, dopaminergic | IEA | neuron, Synap, Neurotransmitter, dopamine (GO term level: 10) | - |
GO:0021952 | central nervous system projection neuron axonogenesis | ISS | neuron, axon (GO term level: 14) | - |
GO:0033603 | positive regulation of dopamine secretion | ISS | dopamine (GO term level: 11) | - |
GO:0042053 | regulation of dopamine metabolic process | ISS | dopamine (GO term level: 9) | - |
GO:0048814 | regulation of dendrite morphogenesis | ISS | dendrite (GO term level: 13) | - |
GO:0001666 | response to hypoxia | IDA | | 12189247 |
GO:0001661 | conditioned taste aversion | IEA | | - |
GO:0007165 | signal transduction | IDA | | 8906617 |
GO:0008542 | visual learning | IMP | | 15964197 |
GO:0007626 | locomotory behavior | ISS | | - |
GO:0007613 | memory | IMP | | 15964197 |
GO:0007605 | sensory perception of sound | ISS | | - |
GO:0007601 | visual perception | ISS | | - |
GO:0006816 | calcium ion transport | ISS | | - |
GO:0006811 | ion transport | NAS | | 8906617 |
GO:0006939 | smooth muscle contraction | ISS | | - |
GO:0042220 | response to cocaine | ISS | | - |
GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep | ISS | | - |
GO:0021562 | vestibulocochlear nerve development | ISS | | - |
GO:0042113 | B cell activation | ISS | | - |
GO:0030890 | positive regulation of B cell proliferation | ISS | | - |
GO:0019233 | sensory perception of pain | ISS | | - |
GO:0021771 | lateral geniculate nucleus development | ISS | | - |
GO:0035176 | social behavior | ISS | | - |
GO:0035095 | behavioral response to nicotine | IMP | | 17559419 |
GO:0045759 | negative regulation of action potential | ISS | | - |
GO:0045188 | regulation of circadian sleep/wake cycle, non-REM sleep | IEA | | - |
GO:0045471 | response to ethanol | ISS | | - |
GO:0050890 | cognition | IMP | | 17559419 |
GO:0051899 | membrane depolarization | ISS | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | IDA | Neurotransmitter (GO term level: 9) | 8906617 |
GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
GO:0016021 | integral to membrane | NAS | | 8906617 |
GO:0009897 | external side of plasma membrane | ISS | | - |
GO:0005886 | plasma membrane | IEA | | - |
GO:0030054 | cell junction | IEA | | - |
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