Gene Page: FGD4

Summary
GeneID  121512
Symbol  FGD4
Synonyms  CMT4H|DKFZp313E1818|DKFZp434K1572|FLJ34370|FLJ42663|FRABP|MGC57222|ZFYVE6
Description  FYVE, RhoGEF and PH domain containing 4
See related  HGNC:19125|MIM:611104|Ensembl:ENSG00000139132|HPRD:16891|
Locus tag  -
Gene type  protein-coding
Map location  12p11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005085guanyl-nucleotide exchange factor activityISS-
GO:0003779actin bindingIEA-
GO:0005515protein bindingISS-
GO:0008270zinc ion bindingIEA-
GO:0031267small GTPase bindingISS-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0046847filopodium formationISSaxon (GO term level: 10)-
GO:0007010cytoskeleton organizationISS-
GO:0008360regulation of cell shapeISS-
GO:0030036actin cytoskeleton organizationISS-
GO:0035023regulation of Rho protein signal transductionIEA-
GO:0043088regulation of Cdc42 GTPase activityISS-
GO:0030032lamellipodium biogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030175filopodiumIEAaxon (GO term level: 5)-
GO:0001726ruffleISS-
GO:0005794Golgi apparatusISS-
GO:0005856cytoskeletonIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmISS-
GO:0030027lamellipodiumISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscle-HPRD9668039 |11429692 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
KORKOLA_SEMINOMA_UP 4427All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
WHITEHURST_PACLITAXEL_SENSITIVITY 3919All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_PR_DN 4434All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
MIKKELSEN_NPC_LCP_WITH_H3K4ME3 5834All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway


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