Gene Page: CSF1R

Summary
GeneID  1436
Symbol  CSF1R
Synonyms  C-FMS|CD115|CSFR|FIM2|FMS
Description  colony stimulating factor 1 receptor
See related  HGNC:2433|MIM:164770|Ensembl:ENSG00000182578|HPRD:01269|
Locus tag  -
Gene type  protein-coding
Map location  5q33-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005011macrophage colony stimulating factor receptor activityTAS8981357 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8981357 
GO:0008283cell proliferationTAS8981357 
GO:0007275multicellular organismal developmentTAS8981357 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS2421165 
GO:0005887integral to plasma membraneTAS2421165 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID11847211 
CSF1MCSF | MGC31930colony stimulating factor 1 (macrophage)-HPRD,BioGRID2408759 |8355686 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID7681396 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2Reconstituted ComplexBioGRID9857184 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID8262059 |9178909 
|9380408 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaCSF1R (c-FMS) interacts with INPP5D. This interaction was modeled on a demonstrated interaction between CSF1R and INPP5D from unspecified species.BIND15735664 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1CSF1R (c-FMS) interacts with INPPL1 (SHIP-2). This interaction was modeled on a demonstrated interaction between CSF1R and INPPL1 from unspecified species.BIND15735664 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID7636265 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID8947469 
CSF1R (c-FMS) interacts with PIK3R1 (PI3'-k).his interaction was modeled on a demonstrated interaction between CSF1R and PIK3R1 from unspecified species.BIND15735664 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD1334406 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID2172781 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID10022833 |11297560 
Socs1 interacts with CSF1-R. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID12133942 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID7681396 
THOC5C22orf19 | Fmip | PK1.3 | fSAP79THO complex 5-HPRD10597251 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD,BioGRID7681396 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_ETS_PATHWAY 1812All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
FERRANDO_TAL1_NEIGHBORS 2115All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_DN 2015All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_DN 2012All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
VISALA_AGING_LYMPHOCYTE_UP 107All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1557637701A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-225946011A,m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-34/4491921991A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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