Gene Page: CSK

Summary
GeneID  1445
Symbol  CSK
Synonyms  MGC117393
Description  c-src tyrosine kinase
See related  HGNC:2444|MIM:124095|Ensembl:ENSG00000103653|HPRD:00496|
Locus tag  -
Gene type  protein-coding
Map location  15q23-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0102 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
UBE3A0.970.97
IPO70.960.97
BCLAF10.960.97
DIS30.950.96
ZMYM20.950.96
FYTTD10.950.96
CAND10.950.97
KPNA40.950.95
SMEK20.950.95
PPP2R5E0.950.96
Top 10 negatively co-expressed genes
FXYD1-0.77-0.86
MT-CO2-0.75-0.85
AF347015.31-0.74-0.83
AF347015.33-0.73-0.81
HIGD1B-0.73-0.84
IFI27-0.72-0.83
MT-CYB-0.72-0.81
TSC22D4-0.71-0.78
HSD17B14-0.71-0.76
AF347015.8-0.71-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008022protein C-terminus bindingTAS8890164 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS1945408 
GO:0008285negative regulation of cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS8890164 
GO:0005911cell-cell junctionIEA-
GO:0005886plasma membraneEXP15574420 
GO:0005886plasma membraneIPI10790433 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID10753943 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID11805080 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID11149930 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD9172452 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD11084024 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)CDH5 (VE-cadherin) interacts with CSK.BIND15861137 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID10801129 
CSKMGC117393c-src tyrosine kinaseCSK autophosphorylates. This interaction was modeled on a demonstrated interaction using CSK from an unspecified species.BIND12588871 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID12473651 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)Affinity Capture-Western
Reconstituted Complex		BioGRID11724572 
DOK3DOKL | FLJ22570 | FLJ39939docking protein 3-HPRD10733577 |14993273 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Affinity Capture-MSBioGRID16729043 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)Affinity Capture-MSBioGRID16729043 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID8262983 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein K-HPRD,BioGRID12052863 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorCSK interacts with IGF-IR.BIND10026153 
-HPRD,BioGRID10026153 
INSRCD220 | HHF5insulin receptorCSK interacts with IR.BIND10026153 
-HPRD,BioGRID10026153 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD,BioGRID10790433 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID9624175 
PLD2-phospholipase D2-HPRD12697812 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID7529872 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12-HPRD11158295 
PXNFLJ16691paxillin-HPRD,BioGRID7529872 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID7544435 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16CSK phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between CSK from an unspecified species and human RSG16.BIND12588871 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD,BioGRID9553134 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID10037694 |12048194 
SIT1MGC125908 | MGC125909 | MGC125910 | RP11-331F9.5 | SITsignaling threshold regulating transmembrane adaptor 1-HPRD11433379 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID7513429 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1Reconstituted ComplexBioGRID9858471 
YTHDC1KIAA1966 | YT521 | YT521-BYTH domain containing 1Affinity Capture-Western
Biochemical Activity		BioGRID15175272 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_SRCRPTP_PATHWAY 119All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 1615All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_PD1_SIGNALING 1814All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
CEBALLOS_TARGETS_OF_TP53_AND_MYC_DN 3831All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN 2616All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN 5132All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_DN 1513All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-140635641m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-216303309m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-249298m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-299-5p6346401Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-3426166221Ahsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-365374380m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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