Gene Page: CTLA4

Summary
GeneID  1493
Symbol  CTLA4
Synonyms  CD152|CELIAC3|CTLA-4|GSE|IDDM12
Description  cytotoxic T-lymphocyte-associated protein 4
See related  HGNC:2505|MIM:123890|Ensembl:ENSG00000163599|HPRD:00474|
Locus tag  -
Gene type  protein-coding
Map location  2q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseIEA-
GO:0006955immune responseTAS3220103 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneTAS3220103 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1M1AP47 | CLAPM2 | CLTNM | MU-1Aadaptor-related protein complex 1, mu 1 subunit-HPRD,BioGRID9812899 |11583591 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitAffinity Capture-Western
Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID9200449 |11583591 
-HPRD9200449 |9256472 
|11583591|9256472 
CD80CD28LG | CD28LG1 | LAB7CD80 molecule-HPRD,BioGRID7545666 
CD80 interacts with CTLA-4.BIND15610849 
CD86B7-2 | B70 | CD28LG2 | LAB72 | MGC34413CD86 molecule-HPRD,BioGRID11021528 |11279501 
CTLA4CD152 | CELIAC3 | CTLA-4 | GSE | IDDM12cytotoxic T-lymphocyte-associated protein 4Co-crystal StructureBioGRID11279502 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9712716 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)CTLA-4 interacts with Jak2.BIND10842319 
-HPRD,BioGRID10842319 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9712716 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID9712716 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD7807015 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoform-HPRD,BioGRID11994459 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID8638161 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_CTLA4_INHIBITORY_SIGNALING 2115All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_DN 4430All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T4 9469All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P4 10062All SZGR genes in this pathway
GAVIN_PDE3B_TARGETS 2215All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_UP 2616All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
BOSCO_TH1_CYTOTOXIC_MODULE 11462All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-155260266m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-33109411001Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-42147531Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-93063121Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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