Gene Page: CTNND2

Summary
GeneID  1501
Symbol  CTNND2
Synonyms  GT24|NPRAP
Description  catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
See related  HGNC:2516|MIM:604275|Ensembl:ENSG00000169862|HPRD:09181|
Locus tag  -
Gene type  protein-coding
Map location  5p15.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
S100B0.800.87
C10orf1160.740.88
PTGDS0.730.85
FXYD10.730.87
S100A10.720.87
HSD17B140.720.84
MYL30.710.84
S100A130.700.86
GSDMD0.700.77
ROM10.690.84
Top 10 negatively co-expressed genes
RNASEN-0.64-0.80
HEATR5B-0.63-0.76
C10orf137-0.63-0.78
ZFP28-0.63-0.79
PURG-0.63-0.77
STAU1-0.62-0.76
RNF145-0.62-0.77
TOPBP1-0.62-0.76
PABPC4-0.62-0.77
COPG2-0.62-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048167regulation of synaptic plasticityIEASynap (GO term level: 8)-
GO:0007158neuron adhesionNASneuron (GO term level: 5)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007155cell adhesionTAS9223106 
GO:0006350transcriptionIEA-
GO:0007165signal transductionTAS9223106 
GO:0007612learningIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS9342840 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD11891774 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Two-hybridBioGRID10332026 
CTTNEMS1 | FLJ34459cortactin-HPRD12835311 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD11821434 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD12835311 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD12835311 
LRRC7DKFZp686I1147 | KIAA1365 | MGC144918leucine rich repeat containing 7-HPRD,BioGRID11729199 
PDZD2AIPC | KIAA0300 | PAPIN | PDZK3 | PIN1PDZ domain containing 2-HPRD,BioGRID10896674 
PAPIN interacts with NPRAP. This interaction was modeled on a demonstrated interaction between rat PAPIN and NPRAP from an unidentified species.BIND10896674 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS1 interacts with NPRAPBIND10037471 
PSEN2AD3L | AD4 | PS2 | STM2presenilin 2 (Alzheimer disease 4)-HPRD10037471 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
HAN_JNK_SINGALING_UP 3521All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP 7353All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP 11370All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2067807861Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-129-5p6626681Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-141/200a8868931A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-1868718771Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429699705m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2183413481A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-26133013371A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-299-5p129312991Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-5p396402m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-31468474m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-328132213281Ahsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
miR-34/449813819m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b8148211A,m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-361712718m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-493-5p505511m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4954764821Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496135113571Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-543157015761Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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