Gene Page: ADRB3

Summary
GeneID  155
Symbol  ADRB3
Synonyms  BETA3AR
Description  adrenergic, beta-3-, receptor
See related  HGNC:288|MIM:109691|Ensembl:ENSG00000188778|HPRD:00188|
Locus tag  -
Gene type  protein-coding
Map location  8p12-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PSMD130.880.91
DUT0.860.85
TMEM106C0.860.90
SAMM500.850.84
POLR2G0.850.85
HTRA20.850.88
COPS60.840.85
VPS250.840.87
MRPL110.840.85
C11orf790.840.86
Top 10 negatively co-expressed genes
AF347015.8-0.66-0.69
AF347015.2-0.66-0.72
AF347015.26-0.66-0.74
AF347015.15-0.66-0.71
AF347015.27-0.65-0.69
MT-CYB-0.65-0.69
MT-CO2-0.64-0.65
AF347015.33-0.63-0.69
AF347015.31-0.60-0.64
MT-ATP8-0.60-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0051380norepinephrine bindingIDANeurotransmitter (GO term level: 4)15123695 
GO:0004872receptor activityIEA-
GO:0015052beta3-adrenergic receptor activityIMP9892244 
GO:0042803protein homodimerization activityIDA15123695 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinIDA15123695 
GO:0007190activation of adenylate cyclase activityIDA15123695 
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS1718744 
GO:0006112energy reserve metabolic processTAS1718744 
GO:0006091generation of precursor metabolites and energyTAS2570461 
GO:0005975carbohydrate metabolic processTAS2570461 
GO:0007165signal transductionIEA-
GO:0006898receptor-mediated endocytosisIDA15123695 
GO:0043410positive regulation of MAPKKK cascadeIDA15123695 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexIDANeurotransmitter (GO term level: 4)15123695 
GO:0005886plasma membraneTAS1718744 
GO:0005887integral to plasma membraneTAS1718744 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GNASAHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3GNAS complex locus-HPRD8011597 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID11013230 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN 5533All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8P12_P11_AMPLICON 5732All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
NADLER_HYPERGLYCEMIA_AT_OBESITY 5835All SZGR genes in this pathway
STAEGE_EWING_FAMILY_TUMOR 3322All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_TROGLITAZONE_DN 4224All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_DN 8450All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
LI_ADIPOGENESIS_BY_ACTIVATED_PPARG 1712All SZGR genes in this pathway
SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_DN 2111All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_UP 4940All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN 4934All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
VERNOCHET_ADIPOGENESIS 1911All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/985215281A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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