Gene Page: ADRBK2

Summary
GeneID  157
Symbol  ADRBK2
Synonyms  BARK2|GRK3
Description  adrenergic, beta, receptor kinase 2
See related  HGNC:290|MIM:109636|Ensembl:ENSG00000100077|HPRD:00183|
Locus tag  -
Gene type  protein-coding
Map location  22q11|22q12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RNF1230.910.90
NISCH0.900.90
SLC45A10.900.89
AP1B10.900.89
ATP6AP10.900.90
ATP13A20.890.90
ABCB90.890.87
AP2A20.890.89
SLC27A40.890.90
FAM134A0.880.87
Top 10 negatively co-expressed genes
AF347015.21-0.67-0.63
AP002478.3-0.62-0.61
MT-CO2-0.62-0.57
AF347015.31-0.62-0.56
AF347015.8-0.61-0.56
NOSTRIN-0.61-0.56
GNG11-0.60-0.59
AF347015.33-0.59-0.53
MT-CYB-0.59-0.53
AF347015.2-0.58-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0004703G-protein coupled receptor kinase activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0047696beta-adrenergic receptor kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8427589 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005886plasma membraneIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCR4CC-CKR-4 | CD194 | CKR4 | CMKBR4 | ChemR13 | HGCN:14099 | K5-5 | MGC88293chemokine (C-C motif) receptor 4-HPRD,BioGRID10754297 
CXCR4CD184 | D2S201E | FB22 | HM89 | HSY3RR | LAP3 | LCR1 | LESTR | NPY3R | NPYR | NPYRL | NPYY3R | WHIMchemokine (C-X-C motif) receptor 4-HPRD,BioGRID11668182 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD,BioGRID9826657 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_OLFACTORY_TRANSDUCTION 38985All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_11Q23_DELETION 2318All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_UP 2411All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway


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