Gene Page: DDC

Summary
GeneID  1644
Symbol  DDC
Synonyms  AADC
Description  dopa decarboxylase (aromatic L-amino acid decarboxylase)
See related  HGNC:2719|MIM:107930|Ensembl:ENSG00000132437|HPRD:00145|
Locus tag  -
Gene type  protein-coding
Map location  7p12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MED130.960.97
MED10.960.97
CNOT60.960.96
AP1GBP10.960.98
AFF40.960.96
LATS10.960.96
PRKDC0.960.97
ZNF518B0.950.97
PBRM10.950.96
NCOA30.950.96
Top 10 negatively co-expressed genes
AF347015.31-0.70-0.86
FXYD1-0.70-0.86
MT-CO2-0.70-0.87
IFI27-0.68-0.85
AF347015.27-0.68-0.83
AIFM3-0.68-0.74
AF347015.33-0.68-0.82
S100B-0.68-0.80
HIGD1B-0.67-0.85
HLA-F-0.67-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004058aromatic-L-amino-acid decarboxylase activityIDA16338639 
GO:0005515protein bindingIPI12864730 
GO:0016829lyase activityIEA-
GO:0016831carboxy-lyase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006519cellular amino acid and derivative metabolic processIEA-
GO:0019752carboxylic acid metabolic processIEA-
GO:0042423catecholamine biosynthetic processIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Reconstituted ComplexBioGRID12864730 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HISTIDINE_METABOLISM 2919All SZGR genes in this pathway
KEGG_TYROSINE_METABOLISM 4230All SZGR genes in this pathway
KEGG_PHENYLALANINE_METABOLISM 1812All SZGR genes in this pathway
KEGG_TRYPTOPHAN_METABOLISM 4033All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_AMINE_DERIVED_HORMONES 1512All SZGR genes in this pathway
IGARASHI_ATF4_TARGETS_DN 9065All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
DIERICK_SEROTONIN_FUNCTION_GENES 66All SZGR genes in this pathway
JEON_SMAD6_TARGETS_DN 1914All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_DN 1914All SZGR genes in this pathway
SMITH_LIVER_CANCER 4527All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_DN 2617All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_DN 3023All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP 8251All SZGR genes in this pathway
HARRIS_BRAIN_CANCER_PROGENITORS 4423All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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