Gene Page: DOCK2

Summary
GeneID  1794
Symbol  DOCK2
Synonyms  FLJ46592|KIAA0209
Description  dedicator of cytokinesis 2
See related  HGNC:2988|MIM:603122|Ensembl:ENSG00000134516|HPRD:09121|
Locus tag  -
Gene type  protein-coding
Map location  5q35.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTPRK0.650.76
TNFAIP20.650.66
GRIP20.620.57
ZNF1850.610.53
PTPN130.610.74
ARHGAP210.610.66
LRRN30.600.57
KDM4C0.600.63
SMPDL3A0.590.60
SPINT10.590.41
Top 10 negatively co-expressed genes
AF347015.21-0.44-0.43
S100A16-0.44-0.44
METRN-0.43-0.47
IFI27-0.43-0.40
CST3-0.43-0.43
REEP6-0.42-0.41
PLA2G5-0.42-0.45
AF347015.31-0.42-0.39
ENHO-0.42-0.48
IL32-0.41-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005506iron ion bindingIEA-
GO:0005515protein bindingIPI12134158 
GO:0020037heme bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0042608T cell receptor bindingIDA12176041 
GO:0030676Rac guanyl-nucleotide exchange factor activityIDA10559471 
GO:0030675Rac GTPase activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001771formation of immunological synapseIEASynap (GO term level: 6)-
GO:0001766membrane raft polarizationIEA-
GO:0001768establishment of T cell polarityIEA-
GO:0007010cytoskeleton organizationIEA-
GO:0006935chemotaxisIEA-
GO:0030036actin cytoskeleton organizationTAS12176041 
GO:0048247lymphocyte chemotaxisISS11518968 
GO:0045060negative thymic T cell selectionIEA-
GO:0045059positive thymic T cell selectionIEA-
GO:0046633alpha-beta T cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005829cytosolEXP14737186 
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD,BioGRID12176041 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID12393632 
ELMO1CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406engulfment and cell motility 1Dock2 interacts with ELMOBIND15723800 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2Reconstituted ComplexBioGRID12176041 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID10559471 
RAC2EN-7 | Gx | HSPC022ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)-HPRD,BioGRID10559471 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID12393632 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_RAC1_REG_PATHWAY 3825All SZGR genes in this pathway
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 132101All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
WINTER_HYPOXIA_DN 5230All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_DN 5839All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
GYORFFY_MITOXANTRONE_RESISTANCE 5735All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_DN 3025All SZGR genes in this pathway


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