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GeneID |
1813
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Symbol |
DRD2
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Synonyms |
D2DR|D2R
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Description |
dopamine receptor D2 |
See related |
HGNC:3023|MIM:126450|Ensembl:ENSG00000149295|HPRD:00539| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
11q23 |
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Gene set name |
Method of gene set |
Evidence |
Info |
Association | A combined odds ratio method (Sun et al. 2008), association studies | 3 | Link to SZGene | GSMA_I | genome scan meta-analysis | Psr: 0.006 | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizophrenic] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 16 | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
Top 10 negatively co-expressed genes | |
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0004952 | dopamine receptor activity | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
GO:0001670 | dopamine D2 receptor activity | IDA | dopamine (GO term level: 10) | 8301582 |
GO:0004872 | receptor activity | IEA | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0048755 | branching morphogenesis of a nerve | ISS | neuron (GO term level: 6) | - |
GO:0007416 | synaptogenesis | ISS | Synap (GO term level: 6) | - |
GO:0007409 | axonogenesis | ISS | neuron, axon, neurite (GO term level: 12) | - |
GO:0060160 | negative regulation of dopamine receptor signaling pathway | ISS | dopamine (GO term level: 10) | - |
GO:0060158 | dopamine receptor, phospholipase C activating pathway | IGI | dopamine (GO term level: 10) | 17194762 |
GO:0051586 | positive regulation of dopamine uptake | ISS | dopamine (GO term level: 12) | - |
GO:0051967 | negative regulation of synaptic transmission, glutamatergic | ISS | neuron, glutamate, Synap, Neurotransmitter (GO term level: 10) | - |
GO:0007270 | nerve-nerve synaptic transmission | ISS | neuron, Synap (GO term level: 7) | - |
GO:0048169 | regulation of long-term neuronal synaptic plasticity | ISS | neuron, Synap (GO term level: 10) | - |
GO:0032228 | regulation of synaptic transmission, GABAergic | ISS | neuron, GABA, Synap, Neurotransmitter (GO term level: 9) | - |
GO:0021853 | cerebral cortex GABAergic interneuron migration | ISS | neuron, GABA (GO term level: 14) | - |
GO:0042417 | dopamine metabolic process | IC | Neurotransmitter, dopamine (GO term level: 8) | 8301582 |
GO:0001659 | temperature homeostasis | ISS | | - |
GO:0002052 | positive regulation of neuroblast proliferation | ISS | | - |
GO:0002027 | regulation of heart rate | ISS | | - |
GO:0002028 | regulation of sodium ion transport | ISS | | - |
GO:0001975 | response to amphetamine | ISS | | - |
GO:0001976 | regulation of systemic arterial blood pressure by neurological process | ISS | | - |
GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | | - |
GO:0007165 | signal transduction | IEA | | - |
GO:0008285 | negative regulation of cell proliferation | ISS | | - |
GO:0008306 | associative learning | ISS | | - |
GO:0008542 | visual learning | ISS | | - |
GO:0009416 | response to light stimulus | ISS | | - |
GO:0007628 | adult walking behavior | ISS | | - |
GO:0007626 | locomotory behavior | ISS | | - |
GO:0008104 | protein localization | ISS | | - |
GO:0007608 | sensory perception of smell | ISS | | - |
GO:0042493 | response to drug | ISS | | - |
GO:0021984 | adenohypophysis development | ISS | | - |
GO:0030432 | peristalsis | ISS | | - |
GO:0051209 | release of sequestered calcium ion into cytosol | ISS | | - |
GO:0030814 | regulation of cAMP metabolic process | IDA | | 8666994 |
GO:0030146 | diuresis | ISS | | - |
GO:0030147 | natriuresis | ISS | | - |
GO:0032922 | circadian regulation of gene expression | ISS | | - |
GO:0030384 | phosphoinositide metabolic process | ISS | | - |
GO:0030336 | negative regulation of cell migration | ISS | | - |
GO:0043278 | response to morphine | ISS | | - |
GO:0043266 | regulation of potassium ion transport | ISS | | - |
GO:0048148 | behavioral response to cocaine | ISS | | - |
GO:0048149 | behavioral response to ethanol | ISS | | - |
GO:0050709 | negative regulation of protein secretion | IDA | | 16839358 |
GO:0050482 | arachidonic acid secretion | IDA | | 8301582 |
GO:0060124 | positive regulation of growth hormone secretion | ISS | | - |
GO:0045776 | negative regulation of blood pressure | ISS | | - |
GO:0051898 | negative regulation of protein kinase B signaling cascade | ISS | | - |
GO:0060134 | prepulse inhibition | ISS | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0030425 | dendrite | ISS | neuron, axon, dendrite (GO term level: 6) | - |
GO:0030424 | axon | ISS | neuron, axon, Neurotransmitter (GO term level: 6) | - |
GO:0016021 | integral to membrane | IEA | | - |
GO:0005886 | plasma membrane | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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