Gene Page: DRD2

Summary
GeneID  1813
Symbol  DRD2
Synonyms  D2DR|D2R
Description  dopamine receptor D2
See related  HGNC:3023|MIM:126450|Ensembl:ENSG00000149295|HPRD:00539|
Locus tag  -
Gene type  protein-coding
Map location  11q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizophrenic]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 16 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004952dopamine receptor activityIEANeurotransmitter, dopamine (GO term level: 8)-
GO:0001670dopamine D2 receptor activityIDAdopamine (GO term level: 10)8301582 
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048755branching morphogenesis of a nerveISSneuron (GO term level: 6)-
GO:0007416synaptogenesisISSSynap (GO term level: 6)-
GO:0007409axonogenesisISSneuron, axon, neurite (GO term level: 12)-
GO:0060160negative regulation of dopamine receptor signaling pathwayISSdopamine (GO term level: 10)-
GO:0060158dopamine receptor, phospholipase C activating pathwayIGIdopamine (GO term level: 10)17194762 
GO:0051586positive regulation of dopamine uptakeISSdopamine (GO term level: 12)-
GO:0051967negative regulation of synaptic transmission, glutamatergicISSneuron, glutamate, Synap, Neurotransmitter (GO term level: 10)-
GO:0007270nerve-nerve synaptic transmissionISSneuron, Synap (GO term level: 7)-
GO:0048169regulation of long-term neuronal synaptic plasticityISSneuron, Synap (GO term level: 10)-
GO:0032228regulation of synaptic transmission, GABAergicISSneuron, GABA, Synap, Neurotransmitter (GO term level: 9)-
GO:0021853cerebral cortex GABAergic interneuron migrationISSneuron, GABA (GO term level: 14)-
GO:0042417dopamine metabolic processICNeurotransmitter, dopamine (GO term level: 8)8301582 
GO:0001659temperature homeostasisISS-
GO:0002052positive regulation of neuroblast proliferationISS-
GO:0002027regulation of heart rateISS-
GO:0002028regulation of sodium ion transportISS-
GO:0001975response to amphetamineISS-
GO:0001976regulation of systemic arterial blood pressure by neurological processISS-
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
GO:0008285negative regulation of cell proliferationISS-
GO:0008306associative learningISS-
GO:0008542visual learningISS-
GO:0009416response to light stimulusISS-
GO:0007628adult walking behaviorISS-
GO:0007626locomotory behaviorISS-
GO:0008104protein localizationISS-
GO:0007608sensory perception of smellISS-
GO:0042493response to drugISS-
GO:0021984adenohypophysis developmentISS-
GO:0030432peristalsisISS-
GO:0051209release of sequestered calcium ion into cytosolISS-
GO:0030814regulation of cAMP metabolic processIDA8666994 
GO:0030146diuresisISS-
GO:0030147natriuresisISS-
GO:0032922circadian regulation of gene expressionISS-
GO:0030384phosphoinositide metabolic processISS-
GO:0030336negative regulation of cell migrationISS-
GO:0043278response to morphineISS-
GO:0043266regulation of potassium ion transportISS-
GO:0048148behavioral response to cocaineISS-
GO:0048149behavioral response to ethanolISS-
GO:0050709negative regulation of protein secretionIDA16839358 
GO:0050482arachidonic acid secretionIDA8301582 
GO:0060124positive regulation of growth hormone secretionISS-
GO:0045776negative regulation of blood pressureISS-
GO:0051898negative regulation of protein kinase B signaling cascadeISS-
GO:0060134prepulse inhibitionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteISSneuron, axon, dendrite (GO term level: 6)-
GO:0030424axonISSneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADORA2AADORA2 | RDC8 | hA2aRadenosine A2a receptor-HPRD,BioGRID12804599 
CLIC6CLIC1Lchloride intracellular channel 6-HPRD,BioGRID14499480 
DRD2D2DR | D2Rdopamine receptor D2D2S receptors form homodimers through Cys126 in the fourth transmembrane segment.BIND12496294 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD12181426 
EPB41L14.1N | DKFZp686H17242 | KIAA0338 | MGC11072erythrocyte membrane protein band 4.1-like 1-HPRD,BioGRID12181426 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)Affinity Capture-WesternBioGRID12181426 
Dopamine receptor D2 interacts with filamin A. This interaction was modeled on a demonstrated interaction between human FLN-A and D2 from unspecified source.BIND11320256 
-HPRD11911837 
FREQDKFZp761L1223 | FLUP | NCS-1 | NCS1frequenin homolog (Drosophila)-HPRD,BioGRID12351722 
The D2 dopamine receptor interacts with NCS-1.BIND12351722 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD10978845 
GNAI387U6 | FLJ26559guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3-HPRD10978845 
GNAZ-guanine nucleotide binding protein (G protein), alpha z polypeptide-HPRD9166747 
KCNJ3GIRK1 | KGA | KIR3.1potassium inwardly-rectifying channel, subfamily J, member 3Affinity Capture-WesternBioGRID12297500 
KCNJ5CIR | GIRK4 | KATP1 | KIR3.4potassium inwardly-rectifying channel, subfamily J, member 5Affinity Capture-WesternBioGRID12297500 
KCNJ6BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2potassium inwardly-rectifying channel, subfamily J, member 6-HPRD,BioGRID12297500 
KCNJ9GIRK3 | KIR3.3potassium inwardly-rectifying channel, subfamily J, member 9-HPRD12297500 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9B-HPRD,BioGRID10391935 
SSTR5-somatostatin receptor 5-HPRD10753124 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY 1717All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP 3823All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3 7959All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a128134m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-2149789841Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-3265275341A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-92892961A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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