Gene Page: DSCAM

Summary
GeneID  1826
Symbol  DSCAM
Synonyms  CHD2-42|CHD2-52
Description  Down syndrome cell adhesion molecule
See related  HGNC:3039|MIM:602523|Ensembl:ENSG00000171587|HPRD:03953|
Locus tag  -
Gene type  protein-coding
Map location  21q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COG10.860.80
MAPRE30.840.78
WIPI20.830.75
RANGAP10.830.79
BAP10.820.79
ZER10.810.77
GPI0.810.78
PGBD50.810.79
ENTPD60.810.81
CACNB10.800.77
Top 10 negatively co-expressed genes
AF347015.21-0.59-0.34
AF347015.18-0.56-0.34
IL32-0.53-0.41
GNG11-0.51-0.40
NOSTRIN-0.49-0.30
AF347015.8-0.49-0.27
MT-CO2-0.48-0.27
MT-ATP8-0.48-0.29
AP002478.3-0.47-0.35
AF347015.2-0.47-0.22
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9426258 
GO:0007155cell adhesionTAS9426258 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005624membrane fractionTAS9426258 
GO:0005886plasma membraneTAS9426258 
GO:0005887integral to plasma membraneTAS9426258 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER interacts with DSCAM-1 enhancer.BIND16009131 
FOXA1HNF3A | MGC33105 | TCF3Aforkhead box A1FOXA1 interacts with DSCAM-1 enhancer.BIND16009131 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaPol II interacts with DSCAM-1 enhancer.BIND16009131 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_DSCAM_INTERACTIONS 1110All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO 3824All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1401391461A,m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-1821001071A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-30-3p135141m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-378*226232m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-961011071Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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