Gene Page: DTX1

Summary
GeneID  1840
Symbol  DTX1
Synonyms  hDx-1
Description  deltex homolog 1 (Drosophila)
See related  HGNC:3060|MIM:602582|Ensembl:ENSG00000135144|HPRD:03991|
Locus tag  -
Gene type  protein-coding
Map location  12q24.13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
THRA0.700.78
ANKDD1A0.700.74
GDF90.690.66
AC100793.20.690.69
CHRNB40.690.70
CUL70.690.72
ZNF4460.680.74
ZNF1850.680.71
PLSCR30.680.69
GTF2H40.680.71
Top 10 negatively co-expressed genes
AF347015.27-0.52-0.66
MT-CO2-0.50-0.65
S100B-0.50-0.63
AF347015.33-0.49-0.64
C5orf53-0.49-0.58
AF347015.31-0.49-0.63
AF347015.8-0.49-0.65
CA4-0.48-0.58
CD8BP-0.48-0.67
MT-CYB-0.47-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityTAS9590294 
GO:0005112Notch bindingIDA11564735 
GO:0005515protein bindingIPI7671825 
GO:0008270zinc ion bindingIEA-
GO:0017124SH3 domain bindingIEA-
GO:0030528transcription regulator activityNAS11564735 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045665negative regulation of neuron differentiationIGIneuron (GO term level: 10)11564735 
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0006366transcription from RNA polymerase II promoterTAS9590294 
GO:0008593regulation of Notch signaling pathwayIGI11564735 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS9590294 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DTX1hDx-1deltex homolog 1 (Drosophila)Affinity Capture-WesternBioGRID11564735 
DTX2KIAA1528 | MGC71098 | RNF58deltex homolog 2 (Drosophila)-HPRD11226752 
DTX3FLJ34766 | MGC138863 | MGC138864 | RNF154deltex 3 homolog (Drosophila)-HPRD11226752 
DTX3LBBAPdeltex 3-like (Drosophila)-HPRD,BioGRID12670957 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID11564735 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID9590294 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)Affinity Capture-WesternBioGRID11564735 
NOTCH2AGS2 | hN2Notch homolog 2 (Drosophila)-HPRD9244302 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_DN 5839All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP 5335All SZGR genes in this pathway
MORI_PLASMA_CELL_DN 3320All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_UP 4532All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_UP 8962All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
MARSHALL_VIRAL_INFECTION_RESPONSE_DN 2921All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12810521058m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-138957963m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-204/21110101016m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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