Gene Page: DYRK1A

Summary
GeneID  1859
Symbol  DYRK1A
Synonyms  DYRK|DYRK1|HP86|MNB|MNBH
Description  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
See related  HGNC:3091|MIM:600855|Ensembl:ENSG00000157540|HPRD:09018|
Locus tag  -
Gene type  protein-coding
Map location  21q22.13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANAPC10.830.87
TUBGCP40.830.86
ANKRD280.820.87
CEP680.820.87
ADAR0.820.87
MYH100.820.84
SMG70.820.87
LIN540.820.85
VPS13B0.820.84
KIAA09470.820.87
Top 10 negatively co-expressed genes
FXYD1-0.66-0.70
HIGD1B-0.65-0.72
MT-CO2-0.64-0.70
AF347015.31-0.64-0.68
AF347015.21-0.63-0.73
TLCD1-0.62-0.66
AC021016.1-0.62-0.65
AF347015.33-0.61-0.64
IFI27-0.61-0.67
CST3-0.61-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityISS-
GO:0004715non-membrane spanning protein tyrosine kinase activityIDA9748265 
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
GO:0043621protein self-associationIEA-
GO:0043621protein self-associationISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8769099 
GO:0018108peptidyl-tyrosine phosphorylationISS-
GO:0046777protein amino acid autophosphorylationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0016607nuclear speckISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCNL2ANIA-6B | CCNM | DKFZp761A1210 | DKFZp762O195 | HCLA-ISO | HLA-ISO | PCEE | SB138cyclin L2-HPRD,BioGRID14623875 
CREB1CREB | MGC9284cAMP responsive element binding protein 1DYRK1A interacts with and phosphorylates CREB. This interaction was modeled on a demonstrated interaction between human DYRK1A and CREB from rat.BIND15694837 
DNM1DNMdynamin 1Reconstituted ComplexBioGRID11877424 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinDYRK1A interacts with PAHX-AP1.BIND15694837 
-HPRD15694837 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1Biochemical ActivityBioGRID14623875 
SFRS16CLASP | FLJ90109 | SWAP2splicing factor, arginine/serine-rich 16Biochemical ActivityBioGRID14623875 
SFRS4SRP75splicing factor, arginine/serine-rich 4Biochemical ActivityBioGRID14623875 
SFRS5HRS | SRP40splicing factor, arginine/serine-rich 5Biochemical ActivityBioGRID14623875 
WDR68AN11 | HAN11WD repeat domain 68Affinity Capture-Western
Co-purification		BioGRID14593110 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
REACTOME_G0_AND_EARLY_G1 2513All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN 4129All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
CHEOK_RESPONSE_TO_HD_MTX_DN 2418All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
CROMER_METASTASIS_UP 7946All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN 12386All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D5 3926All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_DN 5128All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
FINETTI_BREAST_CANCERS_KINOME_GRAY 1510All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_DN 3019All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
LOPEZ_TRANSLATION_VIA_FN1_SIGNALING 3521All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9819051911m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1015205271A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-129-5p234723531Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-137763769m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1445215271Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-145142114281A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/1527547611A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-150183818451A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d13451351m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-182330336m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-192/215198519921A,m8hsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-193785791m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-203.18698751Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/211159165m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-21693991Ahsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-2175155221A,m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-261441501Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-27124412501Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-3p9209261Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-330106710741A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3469039091Ahsa-miR-346brainUGUCUGCCCGCAUGCCUGCCUCU
miR-36369751Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-378212221281Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-409-5p132213281Ahsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-455130813141Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
hsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-485-3p26162622m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-486246624721Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-4951723m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496268826941Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-54412031209m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
miR-912901296m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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