Gene Page: EFNA1

Summary
GeneID  1942
Symbol  EFNA1
Synonyms  B61|ECKLG|EFL1|EPLG1|LERK1|TNFAIP4
Description  ephrin-A1
See related  HGNC:3221|MIM:191164|Ensembl:ENSG00000169242|HPRD:01858|
Locus tag  -
Gene type  protein-coding
Map location  1q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SEL1L0.950.96
CPEB40.940.95
KIAA12190.940.96
ATRN0.930.95
PDE120.920.94
TAOK10.920.94
ABHD20.920.94
ADAR0.920.94
PDPK10.920.95
EXOC6B0.920.94
Top 10 negatively co-expressed genes
HIGD1B-0.66-0.73
AF347015.31-0.66-0.71
FXYD1-0.65-0.70
MT-CO2-0.65-0.71
AF347015.21-0.64-0.73
C1orf54-0.63-0.77
S100A16-0.63-0.68
IFI27-0.63-0.69
CST3-0.62-0.68
CXCL14-0.62-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0046875ephrin receptor bindingTAS2233719 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007267cell-cell signalingTAS8660976 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8660976 
GO:0031225anchored to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
EPHA1EPH | EPHT | EPHT1 | MGC163163EPH receptor A1-HPRD8755474 |11519828 
EPHA2ECKEPH receptor A2The membrane bound ligand B61 interacts with the receptor ECK. This interaction was modeled on a demonstrated interaction between B61 from human and ECK from mouse.BIND7973638 |8755474 
-HPRD7973638 |8755474 
EPHA3ETK | ETK1 | HEK | HEK4 | TYRO4EPH receptor A3Reconstituted ComplexBioGRID9195962 
EPHA4HEK8 | SEK | TYRO1EPH receptor A4-HPRD8755474 
Affinity Capture-WesternBioGRID10366629 
EPHA5CEK7 | EHK1 | HEK7 | TYRO4EPH receptor A5The membrane bound ligand B61 interacts with the receptor EHK1. This interaction was modeled on a demonstrated interaction between B61 from human and EHK1 from rat.BIND7973638 |8755474 
-HPRD8755474 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5Two-hybridBioGRID16169070 
PPBPB-TG1 | Beta-TG | CTAP-III | CTAP3 | CTAPIII | CXCL7 | LA-PF4 | LDGF | MDGF | NAP-2 | PBP | SCYB7 | TC1 | TC2 | TGB | TGB1 | THBGB | THBGB1pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY 1916All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 3818All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
LAMB_CCND1_TARGETS 1914All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
OSAWA_TNF_TARGETS 106All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEONARD_HYPOXIA 4735All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_UP 7747All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_UP 1212All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G12_UP 3917All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_DN 3325All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_DN 4332All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_DN 3928All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_DN 4029All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-200bc/4291521591A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-223400406m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-485-5p1361431A,m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-92732791Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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