Gene Page: EGF

Summary
GeneID  1950
Symbol  EGF
Synonyms  HOMG4|URG
Description  epidermal growth factor (beta-urogastrone)
See related  HGNC:3229|MIM:131530|Ensembl:ENSG00000138798|HPRD:00578|
Locus tag  -
Gene type  protein-coding
Map location  4q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.9082 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005155epidermal growth factor receptor activating ligand activityTAS9712850 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI12620237 
GO:0008083growth factor activityIDA15611079 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000186activation of MAPKK activityIEA-
GO:0000187activation of MAPK activityTAS9482941 
GO:0001525angiogenesisIDA15611079 
GO:0007173epidermal growth factor receptor signaling pathwayIEA-
GO:0006260DNA replicationTAS9482941 
GO:0007165signal transductionEXP1501243 
GO:0042327positive regulation of phosphorylationIDA15611079 
GO:0051048negative regulation of secretionIDA10559227 
GO:0021940positive regulation of granule cell precursor proliferationIEA-
GO:0048754branching morphogenesis of a tubeIEA-
GO:0045741positive regulation of epidermal growth factor receptor activityIDA15611079 
GO:0045840positive regulation of mitosisIDA15611079 
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP6603475 |8493579 |8639530 
|8845374 |9356464 
|9544989 |10567358 
|10648629 |10734310 
|10913131 |11823423 
|1189409 
GO:0005576extracellular regionIC9712850 
GO:0005615extracellular spaceIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS3491360 
GO:0031093platelet alpha granule lumenEXP6603475 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DUSP3VHRdual specificity phosphatase 3-HPRD1281549 
EGFHOMG4 | URGepidermal growth factor (beta-urogastrone)-HPRD,BioGRID11438527 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD10788520 |12093292 
|12620237|12093292 
EGF interacts with EGFR.BIND15837620 
-HPRD,BioGRID12093292 
EGFR interacts with EGF. This interaction was modelled on a demonstrated interaction between EGFR from human and EGF from mouse.BIND8413296 
An unspecified isoform of EGFR interacts with EGF.BIND15950906 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID12093292 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD,BioGRID12093292 
FGF5HBGF-5 | Smag-82fibroblast growth factor 5-HPRD1658709 
FNBP1FBP17 | KIAA0554 | MGC126804formin binding protein 1Co-localizationBioGRID15252009 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD10973965 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2Phenotypic EnhancementBioGRID9687510 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1-HPRD7730382 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD,BioGRID1334406 
RPS6KA5MGC1911 | MSK1 | MSPK1 | RLPKribosomal protein S6 kinase, 90kDa, polypeptide 5Phenotypic EnhancementBioGRID9687510 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID11796824 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY 1816All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY 4135All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY 4635All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 1813All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION 2514All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 1513All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN 13377All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
BUSA_SAM68_TARGETS_DN 65All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
AGARWAL_AKT_PATHWAY_TARGETS 109All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
WANG_RESPONSE_TO_BEXAROTENE_UP 3417All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
CUI_TCF21_TARGETS_DN 3123All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_DN 2116All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
RAY_ALZHEIMERS_DISEASE 137All SZGR genes in this pathway
PIONTEK_PKD1_TARGETS_UP 3824All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
ELLWOOD_MYC_TARGETS_DN 4027All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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