Gene Page: EIF4A2

Summary
GeneID  1974
Symbol  EIF4A2
Synonyms  BM-010|DDX2B|EIF4A|EIF4F
Description  eukaryotic translation initiation factor 4A, isoform 2
See related  HGNC:3284|MIM:601102|Ensembl:ENSG00000156976|HPRD:03062|
Locus tag  -
Gene type  protein-coding
Map location  3q28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003723RNA bindingIEA-
GO:0003743translation initiation factor activityIEA-
GO:0003743translation initiation factor activityTAS8521730 
GO:0005515protein bindingIPI11408474 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0008026ATP-dependent helicase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS8521730 
GO:0006412translationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP8449919 |12588972 
GO:0016281eukaryotic translation initiation factor 4F complexTAS8521730 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALPIIAPalkaline phosphatase, intestinalAffinity Capture-MSBioGRID17353931 
ATRXATR2 | MGC2094 | MRXHF1 | RAD54 | RAD54L | SFM1 | SHS | XH2 | XNP | ZNF-HXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)Affinity Capture-MSBioGRID17353931 
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2Affinity Capture-MSBioGRID17353931 
CMBLFLJ23617carboxymethylenebutenolidase homolog (Pseudomonas)Affinity Capture-MSBioGRID17353931 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedAffinity Capture-MSBioGRID17353931 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-MSBioGRID17353931 
EIF3DEIF3S7 | MGC126526 | MGC17258 | eIF3-p66 | eIF3-zetaeukaryotic translation initiation factor 3, subunit DAffinity Capture-MSBioGRID17353931 
EIF3EIPEIF3S11 | EIF3S6IP | HSPC021 | HSPC025 | MSTP005eukaryotic translation initiation factor 3, subunit E interacting proteinAffinity Capture-MSBioGRID17353931 
EIF3HEIF3S3 | MGC102958 | eIF3-gamma | eIF3-p40eukaryotic translation initiation factor 3, subunit HAffinity Capture-MSBioGRID17353931 
EIF3KARG134 | EIF3-p28 | EIF3S12 | HSPC029 | M9 | MSTP001 | PLAC-24 | PLAC24 | PRO1474 | PTD001eukaryotic translation initiation factor 3, subunit KAffinity Capture-MSBioGRID17353931 
EIF3MB5 | FLJ29030 | GA17 | PCID1 | hfl-B5eukaryotic translation initiation factor 3, subunit MAffinity Capture-MSBioGRID17353931 
EIF4ECBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573eukaryotic translation initiation factor 4EAffinity Capture-MSBioGRID17353931 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1Affinity Capture-MSBioGRID17353931 
-HPRD11408474 
EIF4G2AAG1 | DAP5 | FLJ41344 | NAT1 | p97eukaryotic translation initiation factor 4 gamma, 2Affinity Capture-MSBioGRID17353931 
EIF4G3eIF4GIIeukaryotic translation initiation factor 4 gamma, 3Affinity Capture-MSBioGRID17353931 
MYO1Bmyr1myosin IBAffinity Capture-MSBioGRID17353931 
P4HBDSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideAffinity Capture-MSBioGRID17353931 
PABPC1PAB1 | PABP | PABP1 | PABPC2 | PABPL1poly(A) binding protein, cytoplasmic 1Affinity Capture-MSBioGRID17353931 
PDCD4H731 | MGC33046 | MGC33047programmed cell death 4 (neoplastic transformation inhibitor)Affinity Capture-MSBioGRID17353931 
PTPRSPTPSIGMAprotein tyrosine phosphatase, receptor type, SAffinity Capture-MSBioGRID17353931 
RPS29-ribosomal protein S29Affinity Capture-MSBioGRID17353931 
SFRS17A721P | CCDC133 | CXYorf3 | DXYS155E | MGC125365 | MGC125366 | MGC39904 | XE7 | XE7Ysplicing factor, arginine/serine-rich 17AAffinity Capture-MSBioGRID17353931 
SPAG9FLJ13450 | FLJ14006 | FLJ26141 | FLJ34602 | HLC4 | JLP | KIAA0516 | MGC117291 | MGC14967 | MGC74461 | PHET | PIG6sperm associated antigen 9Affinity Capture-MSBioGRID17353931 
TPM3FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30tropomyosin 3Affinity Capture-MSBioGRID17353931 
VAC14ArPIKfyve | FLJ10305 | FLJ36622 | FLJ46582 | MGC149815 | MGC149816 | TAX1BP2 | TRXVac14 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_EIF_PATHWAY 169All SZGR genes in this pathway
BIOCARTA_MTOR_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 8430All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 17651All SZGR genes in this pathway
REACTOME_DEADENYLATION_OF_MRNA 2214All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 4829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_CCNE1 4026All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_7 86All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES 4534All SZGR genes in this pathway
JIANG_VHL_TARGETS 13891All SZGR genes in this pathway
MMS_MOUSE_LYMPH_HIGH_4HRS_UP 3620All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP 4533All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_E2 2821All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP 5225All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/212202208m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-137531537m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-145504510m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d6206261Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181596602m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1835675731Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-195745801Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2085825881Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-2172228m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-335159165m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-3774995051Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-3816116171Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4995825881Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-5435976041A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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