Gene Page: ERBB4

Summary
GeneID  2066
Symbol  ERBB4
Synonyms  HER4|MGC138404|p180erbB4
Description  v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
See related  HGNC:3432|MIM:600543|Ensembl:ENSG00000178568|HPRD:02767|
Locus tag  -
Gene type  protein-coding
Map location  2q33.3-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 33.331 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EIF2C10.880.87
ANKFY10.880.90
ZFYVE260.880.89
SEC16A0.880.88
TRRAP0.870.87
EP4000.870.88
ABL10.870.85
RNF144A0.860.85
KIAA03550.860.88
DIP2A0.860.88
Top 10 negatively co-expressed genes
AF347015.31-0.59-0.70
MT-CO2-0.57-0.70
C5orf53-0.57-0.62
HIGD1B-0.57-0.70
IFI27-0.57-0.67
FXYD1-0.56-0.66
C1orf54-0.54-0.75
AF347015.21-0.54-0.74
AF347015.27-0.54-0.65
MYL3-0.54-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)8383326 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI9419975 |10572067 |11867753 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0046982protein heterodimerization activityIDA10572067 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionIDA10572067 
GO:0008283cell proliferationTAS8383326 
GO:0007275multicellular organismal developmentTAS8383326 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8383326 
GO:0016323basolateral plasma membraneIDA12646923 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTC-betacellulin-HPRD11254912 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD,BioGRID11825873 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-MSBioGRID16729043 
CTGFCCN2 | HCS24 | IGFBP8 | MGC102839 | NOV2connective tissue growth factor-HPRD12297288 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID12175853 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID10725395 
ErbB-4 interacts with CHAPSYN-110.BIND10725395 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD,BioGRID10725395 |12175853 
ErbB-4 interacts with SAP-102.BIND10725395 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10725395 
ErbB-4 interacts with PSD-95.BIND10725395 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)Affinity Capture-WesternBioGRID10839362 
EREGERepiregulin-HPRD,BioGRID9419975 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID16729043 
HBEGFDTR | DTS | DTSF | HEGFLheparin-binding EGF-like growth factor-HPRD9135143 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD,BioGRID11278868 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Affinity Capture-MSBioGRID16729043 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1Reconstituted ComplexBioGRID9168115 
-HPRD7721889 |8062828 
|10537356 
NRG2Don-1 | HRG2 | NTAKneuregulin 2-HPRD,BioGRID9168114 |9168115 
NRG3HRG3 | pro-NRG3neuregulin 3-HPRD9275162 
NRG4DKFZp779N0541 | DKFZp779N1944 | HRG4neuregulin 4-HPRD10348342 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Affinity Capture-MSBioGRID16729043 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-MSBioGRID16729043 
RNF41MGC45228 | NRDP1 | SBBI03ring finger protein 41-HPRD,BioGRID11867753 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-MSBioGRID16729043 
SNTB2D16S2531E | EST25263 | SNT2B2 | SNT3 | SNTLsyntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)-HPRD,BioGRID10725395 
ErbB-4 interacts with beta 2-syntropin.BIND10725395 
STAT5AMGF | STAT5signal transducer and activator of transcription 5AAffinity Capture-MS
Affinity Capture-Western		BioGRID15534001 |16729043 
YAP1YAP | YAP2 | YAP65 | YKIYes-associated protein 1, 65kDa-HPRD,BioGRID15023535 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 2017All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN 8453All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ODONNELL_METASTASIS_UP 8258All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_UP 3622All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 9772All SZGR genes in this pathway
FINETTI_BREAST_CANCERS_KINOME_BLUE 2116All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
LIU_TOPBP1_TARGETS 168All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101718471901Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-125/35164826488m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-130/30110801086m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-135556655731A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-137114011471A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-138115611621Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-14368066812m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-144718471901Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-146769276991A,m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-1910791085m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-19391981A,m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-194782578311Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-199103410411A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-205750675131A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-221/222662766341A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-23719972061A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-24*625362601A,m8hsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-261571631Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-3p178184m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-323719972051Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-326502150281A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-330726672731A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-36276987704m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-381732573311Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-383778277881Ahsa-miR-383brainAGAUCAGAAGGUGAUUGUGGCU
miR-495782378291Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-543754375491Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-77379m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520108210881Ahsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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