Gene Page: ERCC4

Summary
GeneID  2072
Symbol  ERCC4
Synonyms  RAD1|XPF
Description  excision repair cross-complementing rodent repair deficiency, complementation group 4
See related  HGNC:3436|MIM:133520|Ensembl:ENSG00000175595|HPRD:00594|
Locus tag  -
Gene type  protein-coding
Map location  16p13.3|16p13.3-p13.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0003684damaged DNA bindingIMP11790111 
GO:0003697single-stranded DNA bindingIDA10413517 
GO:0004520endodeoxyribonuclease activityIDA10413517 |14734547 
GO:0004520endodeoxyribonuclease activityIDA8797827 
GO:0016787hydrolase activityIEA-
GO:0008022protein C-terminus bindingIPI9722633 
GO:0047485protein N-terminus bindingIPI14734547 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0000724double-strand break repair via homologous recombinationIMP14728600 
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesionIMP11790111 
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesionIMP11790111 |14728600 
GO:0009650UV protectionIEA-
GO:0032205negative regulation of telomere maintenanceIMP17055345 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000109nucleotide-excision repair complexIDA10413517 
GO:0000784nuclear chromosome, telomeric regionIDA14690602 
GO:0005634nucleusIDA12571280 
GO:0005654nucleoplasmEXP10214908 |11313499 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ERCC1COFS4 | UV20excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)-HPRD,BioGRID8197175 |9722633 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AAffinity Capture-WesternBioGRID12571280 
SPTA1EL2 | SPTAspectrin, alpha, erythrocytic 1 (elliptocytosis 2)Affinity Capture-WesternBioGRID12571280 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Affinity Capture-WesternBioGRID12571280 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NUCLEOTIDE_EXCISION_REPAIR 4425All SZGR genes in this pathway
REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 4524All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_EXCISION_REPAIR 5127All SZGR genes in this pathway
REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 3013All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_GLOBAL_GENOMIC_NER_GG_NER 3520All SZGR genes in this pathway
REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 2311All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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