Gene Page: ESR2

Summary
GeneID  2100
Symbol  ESR2
Synonyms  ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2
Description  estrogen receptor 2 (ER beta)
See related  HGNC:3468|MIM:601663|Ensembl:ENSG00000140009|HPRD:03390|
Locus tag  -
Gene type  protein-coding
Map location  14q23.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.461 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0521 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FNDC3A0.780.86
FAF20.760.82
IMPAD10.750.83
EAF10.750.82
MAP3K7IP20.740.81
SLC39A90.740.81
MMGT10.740.80
DCTN40.740.80
SEC23B0.740.78
ZFR0.730.80
Top 10 negatively co-expressed genes
FXYD1-0.59-0.62
MT-CO2-0.56-0.60
AF347015.21-0.55-0.60
HIGD1B-0.55-0.60
CSAG1-0.54-0.57
AC098691.2-0.54-0.62
IFI27-0.53-0.57
AF347015.8-0.53-0.58
AF347015.31-0.52-0.58
AF347015.33-0.52-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS8769313 
GO:0003713transcription coactivator activityTAS8769313 
GO:0005496steroid bindingTAS11181953 
GO:0005515protein bindingIPI12039952 |14764652 
GO:0008270zinc ion bindingIEA-
GO:0048019receptor antagonist activityNAS9671811 
GO:0030284estrogen receptor activityTAS11181953 
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentTAS11181953 
GO:0030520estrogen receptor signaling pathwayTAS11181953 
GO:0006350transcriptionIEA-
GO:0007267cell-cell signalingTAS8769313 
GO:0007165signal transductionTAS8769313 |10749889 
GO:0030308negative regulation of cell growthNAS11181953 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS11181953 
GO:0005739mitochondrionIDA15024130 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCAS2DAM1breast carcinoma amplified sequence 2BCAS2 interacts with ER-beta. This interaction was modeled on a demonstrated interaction between human BCAS2 and ER-beta from an unspecified species.BIND15694360 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD11981030 
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD11981030 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD11981030 
DAP3DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10death associated protein 3Reconstituted ComplexBioGRID10903152 
DDX54DP97 | MGC2835DEAD (Asp-Glu-Ala-Asp) box polypeptide 54-HPRD,BioGRID12466272 
DNTTIP2ERBP | FCF2 | HSU15552 | LPTS-RP2 | MGC163494 | RP4-561L24.1 | TdIF2deoxynucleotidyltransferase, terminal, interacting protein 2-HPRD,BioGRID15047147 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER alpha interacts with ER beta to form heterodimer. This interaction was modeled on a demonstrated interaction between human ER alpha and mouse ER beta.BIND10706629 
-HPRD,BioGRID9473491 
MAD2L1HSMAD2 | MAD2MAD2 mitotic arrest deficient-like 1 (yeast)MAD2 interacts with ER beta. This interaction was modeled on a demonstrated interaction between MAD2 from human and sheep and ER beta from rat and mouse.BIND10706629 
-HPRD,BioGRID10706629 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1-HPRD,BioGRID11867769 
MKNK2GPRK7 | MNK2MAP kinase interacting serine/threonine kinase 2-HPRD,BioGRID11013076 
MMS19FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19MMS19 nucleotide excision repair homolog (S. cerevisiae)-HPRD11279242 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID10809226 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD,BioGRID10681591 |11389589 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6-HPRD,BioGRID11773444 
NR0B2FLJ17090 | SHP | SHP1nuclear receptor subfamily 0, group B, member 2-HPRD,BioGRID9773978 |10648597 
OXTMGC126890 | MGC126892 | OT | OT-NPIoxytocin, prepropeptide-HPRD9501254 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1-HPRD,BioGRID12415108 
PIAS2MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | mizprotein inhibitor of activated STAT, 2Reconstituted ComplexBioGRID11117529 
PRMT2HRMT1L1 | MGC111373protein arginine methyltransferase 2PRMT2 interacts with ER-beta.BIND12039952 
PSMC3IPGT198 | HOP2 | HUMGT198A | TBPIPPSMC3 interacting protein-HPRD11739747 
RBM39CAPER | CAPERalpha | CC1.3 | DKFZp781C0423 | FLJ44170 | HCC1 | RNPC2 | fSAP59RNA binding motif protein 39-HPRD,BioGRID11704680 
RBM9FOX2 | Fox-2 | HNRBP2 | HRNBP2 | RTA | dJ106I20.3 | fxhRNA binding motif protein 9-HPRD,BioGRID11875103 
REXO4REX4 | XPMC2 | XPMC2HREX4, RNA exonuclease 4 homolog (S. cerevisiae)-HPRD,BioGRID10908561 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1-HPRD,BioGRID12145209 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID11032808 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID11682624 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD10598587 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD11266503 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideReconstituted ComplexBioGRID11266503 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_ERB_GENOMIC_PATHWAY 158All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 4936All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LI_CYTIDINE_ANALOGS_CYCTOTOXICITY 158All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_UP 2720All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
MATZUK_PREOVULATORY_FOLLICLE 108All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3 3421All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
LI_PROSTATE_CANCER_EPIGENETIC 3022All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway


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