Gene Page: FKBP1A

Summary
GeneID  2280
Symbol  FKBP1A
Synonyms  FKBP-12|FKBP1|FKBP12|FKBP12C|PKC12|PKCI2|PPIASE
Description  FK506 binding protein 1A, 12kDa
See related  HGNC:3711|MIM:186945|Ensembl:ENSG00000088832|HPRD:01741|
Locus tag  RP11-314N13.2
Gene type  protein-coding
Map location  20p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.025 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KANK20.780.82
COLEC120.770.77
TBX180.760.78
FOXC20.760.78
ITIH50.760.85
FLI10.710.79
GPR1240.700.79
MDS10.700.72
EVI10.690.72
CDH50.690.73
Top 10 negatively co-expressed genes
SNHG12-0.34-0.45
ZNF32-0.33-0.50
C12orf45-0.32-0.49
COX7C-0.32-0.42
MTIF3-0.32-0.43
ST20-0.31-0.43
RPS27L-0.31-0.39
ATP5E-0.31-0.50
AC132872.1-0.30-0.40
RPL41-0.30-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005024transforming growth factor beta receptor activityTAS11322937 
GO:0004872receptor activityTAS7518616 
GO:0003755peptidyl-prolyl cis-trans isomerase activityIEA-
GO:0005515protein bindingIPI12604780 
GO:0016853isomerase activityIEA-
GO:0005219ryanodine-sensitive calcium-release channel activityTAS11322937 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0003007heart morphogenesisISS-
GO:0055010ventricular cardiac muscle morphogenesisISS-
GO:0022417protein maturation via protein foldingTAS11322937 
GO:0006457protein foldingIEA-
GO:0006458'de novo' protein foldingTAS11322937 
GO:0042110T cell activationNAS1696686 
GO:0042026protein refoldingTAS11322937 
GO:0032513negative regulation of protein phosphatase type 2B activityIDA7592869 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIMP12761501 
GO:0050776regulation of immune responseIMP2477715 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA1701173 
GO:0005737cytoplasmIEA-
GO:0014802terminal cisternaISS1374404 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IATwo-hybridBioGRID9663660 
DHFR-dihydrofolate reductaseBiochemical ActivityBioGRID12812497 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDa-HPRD,BioGRID9871618 |10852943 
FKBP4FKBP52 | FKBP59 | HBI | Hsp56 | PPIase | p52FK506 binding protein 4, 59kDa-HPRD11164950 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1-HPRD,BioGRID8662507 
mTOR interacts with FKBP12 bound to rapamycin. This interaction was modeled on a demonstrated interaction between human mTOR and mouse FKBP12.BIND15467718 
GLMNFAP | FAP48 | FAP68 | FKBPAP | GLML | GVM | VMGLOMglomulin, FKBP associated protein-HPRD,BioGRID8955134 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1-HPRD,BioGRID9346894 
KIAA1303-raptorAffinity Capture-WesternBioGRID15268862 |15467718 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform-HPRD7543369 
PPP3R1CALNB1 | CNB | CNB1protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform-HPRD7541044 
RYR1CCO | MHS | MHS1 | RYDR | RYR | SKRRryanodine receptor 1 (skeletal)-HPRD,BioGRID11171121 |11279144 
|12704193|11237759 
RYR3-ryanodine receptor 3-HPRD,BioGRID11171121 |11598113 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1-HPRD12417722 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD,BioGRID7518616 
T-beta-R1 interacts with FKBP12. This interaction was modeled on a demonstrated interaction between T-beta-R1 and FKBP12 both from unspecified species.BIND15761148 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3-HPRD15199065 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorTwo-hybridBioGRID7541038 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_MTOR_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 167All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 2616All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_UP 8251All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
WIKMAN_ASBESTOS_LUNG_CANCER_DN 2813All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_UP 4424All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS 3020All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP 7149All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_DN 4429All SZGR genes in this pathway
WU_ALZHEIMER_DISEASE_UP 148All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_UP 2716All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1354674741A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-142-3p6596661A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-181139145m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1832262321Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-2183363421Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367109911051Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-320157163m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-338913919m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p4324381Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374432438m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3811171231Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4104344401Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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