Gene Page: FOXG1

Summary
GeneID  2290
Symbol  FOXG1
Synonyms  BF1|BF2|FHKL3|FKH2|FKHL1|FKHL2|FKHL3|FKHL4|FOXG1A|FOXG1B|FOXG1C|HBF-1|HBF-2|HBF-3|HBF-G2|HBF2|HFK1|HFK2|HFK3|KHL2|QIN
Description  forkhead box G1
See related  HGNC:3811|MIM:164874|Ensembl:ENSG00000176165|HPRD:01283|
Locus tag  -
Gene type  protein-coding
Map location  14q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FOXC20.850.62
CFH0.790.58
GJB20.780.49
SIX20.780.42
OGN0.760.47
SCARA50.750.40
DSP0.750.47
SIX10.740.46
ITGBL10.740.42
OSR10.710.38
Top 10 negatively co-expressed genes
C1orf63-0.17-0.17
AC007216.4-0.16-0.15
SLC25A41-0.15-0.14
SNHG12-0.15-0.31
C11orf51-0.15-0.21
CRYGS-0.15-0.10
KCNMB3-0.14-0.24
CYP2C8-0.14-0.18
NPIP-0.14-0.10
DFNB59-0.14-0.12
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048667cell morphogenesis involved in neuron differentiationIEAneuron (GO term level: 10)-
GO:0016199axon midline choice point recognitionIEAaxon (GO term level: 15)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0021954central nervous system neuron developmentIEAneuron (GO term level: 10)-
GO:0045665negative regulation of neuron differentiationIEAneuron (GO term level: 10)-
GO:0002052positive regulation of neuroblast proliferationIEA-
GO:0006355regulation of transcription, DNA-dependentNAS-
GO:0006350transcriptionIEA-
GO:0007346regulation of mitotic cell cycleIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0042472inner ear morphogenesisIEA-
GO:0045787positive regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
FOXH1FAST-1 | FAST1forkhead box H1-HPRD,BioGRID10938097 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1FoxO1 interacts with FoxG1. This interaction was modelled on an interaction demonstrated between FoxO1 from an unspecified species and mouse FoxG1.BIND15084259 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3FoxO3 interacts with FoxG1.BIND15084259 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4FoxO4 interacts with FoxG1. This interaction was modelled on a demonstrated interaction between human FoxO4 and mouse FoxG1.BIND15084259 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD11238932 
HES1FLJ20408 | HES-1 | HHL | HRY | bHLHb39hairy and enhancer of split 1, (Drosophila)-HPRD11238932 
JARID1BFLJ10538 | FLJ12459 | FLJ12491 | FLJ16281 | FLJ23670 | KDM5B | PLU-1 | PUT1 | RBBP2H1Ajumonji, AT rich interactive domain 1B-HPRD,BioGRID12657635 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD,BioGRID11387330 
TLE1ESG | ESG1 | GRG1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)-HPRD11238932 
TLE3ESG | ESG3 | FLJ39460 | GRG3 | HsT18976 | KIAA1547transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)-HPRD11238932 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_DN 3520All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_UP 3521All SZGR genes in this pathway
LI_WILMS_TUMOR 2712All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_DN 1710All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_UP 3325All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_DN 3025All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-133814m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-144835841m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1864774831Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/4293153221A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.12592651Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2088138191Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-2173133191Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-25/32/92/363/367172178m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-299-5p746752m8hsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-5p874880m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-330251257m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-34/449599605m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-369-3p3173241A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3743183251A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3768808861Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-378*7076m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-4998138191Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-5001701771A,m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
miR-5433923981Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-95185251A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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