Gene Page: SMG1

Summary
GeneID  23049
Symbol  SMG1
Synonyms  61E3.4|ATX|KIAA0421|LIP
Description  PI-3-kinase-related kinase SMG-1
See related  MIM:607032|Ensembl:ENSG00000157106|HPRD:06123|
Locus tag  -
Gene type  protein-coding
Map location  16p12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF6290.930.93
NAV10.930.95
ZMIZ10.930.92
SH3PXD2B0.930.93
DLG50.920.93
BAT2L0.920.92
KIAA15490.910.92
JRK0.910.93
ARID1B0.910.93
TBC1D160.910.90
Top 10 negatively co-expressed genes
C5orf53-0.67-0.77
AF347015.31-0.66-0.86
AF347015.27-0.64-0.83
MT-CO2-0.64-0.84
S100B-0.63-0.77
FXYD1-0.63-0.79
AF347015.33-0.62-0.79
IFI27-0.62-0.77
HIGD1B-0.62-0.80
MT-CYB-0.61-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11544179 
GO:0004428inositol or phosphatidylinositol kinase activityIDA11331269 
GO:0004674protein serine/threonine kinase activityIDA11544179 |15175154 
GO:0004674protein serine/threonine kinase activityNAS11331269 
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIDA11544179 
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayNAS11331269 
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS16488880 
GO:0006406mRNA export from nucleusTAS16488880 
GO:0006281DNA repairIEA-
GO:0018105peptidyl-serine phosphorylationIDA11544179 |15175154 
GO:0018105peptidyl-serine phosphorylationTAS14636577 
GO:0046854phosphoinositide phosphorylationIDA11331269 
GO:0046777protein amino acid autophosphorylationIDA11331269 |11544179 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA14636577 |15175154 
GO:0005737cytoplasmIC11331269 
GO:0005737cytoplasmIDA14636577 |15175154 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD10428027 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iota-HPRD,BioGRID8524286 
PKC-lambda/iota interacts with LIP.BIND8524286 
SMG161E3.4 | ATX | KIAA0421 | LIPPI-3-kinase-related kinase SMG-1Biochemical ActivityBioGRID11544179 
SMG5EST1B | FLJ34864 | KIAA1089 | LPTS-RP1 | LPTSRP1 | RP11-54H19.7 | SMG-5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)-HPRD14636577 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53hSMG-1 phosphorylates p53.BIND15175154 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)-HPRD,BioGRID11544179 
hSMG-1 phosphorylates hUpf1.BIND15175154 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID11544179 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Affinity Capture-WesternBioGRID11544179 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 17657All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
PARK_HSC_VS_MULTIPOTENT_PROGENITORS_UP 1914All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_DN 6435All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP 6229All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE 2018All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_UP 10546All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063513571Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-125/3511751821A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-128888894m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-13845734579m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-142-3p5895961A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-21631473153m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-30-3p458345891Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3293673731Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-33343234391A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-362791797m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-377338533911Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-384145151m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-485-3p466246691A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-485-5p59661A,m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-49032213227m8hsa-miR-490CAACCUGGAGGACUCCAUGCUG
miR-493-5p867873m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-5042102171A,m8hsa-miR-504AGACCCUGGUCUGCACUCUAU
miR-735223528m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.