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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NCOA6

Summary

GeneID

23054

Symbol

NCOA6

Synonyms

AIB3|ANTP|ASC2|HOX1.1|HOXA7|KIAA0181|NRC|PRIP|RAP250|TRBP

Description

nuclear receptor coactivator 6

Locus tag

RP5-1181N3.2

Gene type

protein-coding

Map location

20q11

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ZFYVE20

0.96

TGFBRAP1

0.95

0.96

FOXK2

0.95

DIP2C

0.94

0.95

USP22

0.94

CLIP2

0.93

0.94

RAPGEF1

0.93

0.94

SEC16A

0.93

0.94

PRDM15

0.93

0.94

SLC35E1

0.93

0.94

Top 10 negatively co-expressed genes

AF347015.31

-0.71

-0.78

MT-CO2

-0.69

-0.77

AF347015.21

-0.68

-0.84

AF347015.27

-0.68

-0.74

FXYD1

-0.68

-0.73

HIGD1B

-0.67

-0.75

AF347015.33

-0.66

-0.70

C1orf54

-0.66

-0.83

AF347015.8

-0.66

-0.75

MT-CYB

-0.65

-0.72

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003682

chromatin binding

ISS

GO:0005515

protein binding

IPI

11443112

GO:0030331

estrogen receptor binding

TAS

11443112

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

IPI

11443112

GO:0046965

retinoid X receptor binding

TAS

11443112

GO:0046966

thyroid hormone receptor binding

IDA

11443112

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007420

brain development

ISS

Brain (GO term level: 7)

GO:0001701

in utero embryonic development

ISS

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006367

transcription initiation from RNA polymerase II promoter

ISS

GO:0030520

estrogen receptor signaling pathway

NAS

11443112

GO:0030099

myeloid cell differentiation

IDA

11302752

GO:0006350

transcription

IEA

GO:0006310

DNA recombination

NAS

11443112

GO:0006281

DNA repair

NAS

11443112

GO:0006260

DNA replication

NAS

11443112

GO:0009725

response to hormone stimulus

TAS

11443112

GO:0007507

heart development

ISS

GO:0042921

glucocorticoid receptor signaling pathway

NAS

11443112

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IDA

11443112

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

11443112

GO:0005634

nucleus

NAS

10567404

GO:0005667

transcription factor complex

TAS

11443112

GO:0005730

nucleolus

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Two-hybrid	BioGRID	14645241
ASCC1	ASC1p50 \| CGI-18 \| RP11-150D20.4	activating signal cointegrator 1 complex subunit 1	Reconstituted Complex	BioGRID	10567404
ASCL2	ASH2 \| HASH2 \| MASH2 \| bHLHa45	achaete-scute complex homolog 2 (Drosophila)	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	Affinity Capture-Western Co-localization Reconstituted Complex Two-hybrid	BioGRID	14734562
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	Reconstituted Complex	BioGRID	10497212
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Reconstituted Complex	BioGRID	10847592
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	ASC-2 interacts with C/EBP alpha.	BIND	11302752
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	Affinity Capture-Western Co-localization Two-hybrid	BioGRID	11302752 \|14734562
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331
CXADR	CAR \| HCAR	coxsackie virus and adenovirus receptor	Reconstituted Complex	BioGRID	15764585
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14638867
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	10823961
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331 \|11773444
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD,BioGRID	11773444
FGR	FLJ43153 \| MGC75096 \| SRC2 \| c-fgr \| c-src2 \| p55c-fgr \| p58c-fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	Affinity Capture-Western	BioGRID	12482968
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	Reconstituted Complex	BioGRID	10847592
GTF2A1	MGC129969 \| MGC129970 \| TF2A1 \| TFIIA	general transcription factor IIA, 1, 19/37kDa	Reconstituted Complex	BioGRID	10567404
HBXIP	MGC71071 \| XIP	hepatitis B virus x interacting protein	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14578865
HIST2H3C	H3 \| H3.2 \| H3/M \| H3F2 \| H3FM \| MGC9629	histone cluster 2, H3c	Affinity Capture-Western Reconstituted Complex	BioGRID	12482968
HSAJ2425	p65	p65 protein	Reconstituted Complex	BioGRID	10847592
HSF1	HSTF1	heat shock transcription factor 1	Affinity Capture-Western Co-localization	BioGRID	14960326
HSF1	HSTF1	heat shock transcription factor 1	ASC-2 interacts with HSF1.	BIND	14960326
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	Reconstituted Complex	BioGRID	10847592
MED23	CRSP130 \| CRSP133 \| CRSP3 \| DKFZp434H0117 \| DRIP130 \| SUR2	mediator complex subunit 23	-	HPRD,BioGRID	10823961
MLL3	DKFZp686C08112 \| FLJ12625 \| FLJ38309 \| HALR \| KIAA1506 \| KMT2C \| MGC119851 \| MGC119852 \| MGC119853	myeloid/lymphoid or mixed-lineage leukemia 3	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Reconstituted Complex	BioGRID	10847592
NR1H2	LXR-b \| LXRB \| NER \| NER-I \| RIP15 \| UNR	nuclear receptor subfamily 1, group H, member 2	Reconstituted Complex Two-hybrid	BioGRID	11158331 \|15764585
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	10567404
NUMA1	NUMA	nuclear mitotic apparatus protein 1	-	HPRD,BioGRID	12519782
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	Affinity Capture-MS	BioGRID	12519782
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	Two-hybrid	BioGRID	11158331
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD	10788465
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	Two-hybrid	BioGRID	11158331
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	Affinity Capture-MS Biochemical Activity	BioGRID	10823961
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2 interacts with PRIP.	BIND	12039952
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	-	HPRD,BioGRID	10567404
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with ASC-2.	BIND	14645241
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14645241
RBBP5	RBQ3 \| SWD1	retinoblastoma binding protein 5	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
RBM14	COAA \| DKFZp779J0927 \| MGC15912 \| MGC31756 \| PSP2 \| SIP \| SYTIP1 \| TMEM137	RNA binding motif protein 14	-	HPRD	11443112
RBM39	CAPER \| CAPERalpha \| CC1.3 \| DKFZp781C0423 \| FLJ44170 \| HCC1 \| RNPC2 \| fSAP59	RNA binding motif protein 39	-	HPRD	11704680
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Reconstituted Complex	BioGRID	10847592
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331 \|11773444 \|14578865
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10847592 \|11158331 \|12482968
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	Reconstituted Complex	BioGRID	10847592
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Reconstituted Complex	BioGRID	10567404
TGS1	DKFZp762A163 \| FLJ22995 \| NCOA6IP \| PIMT \| PIPMT	trimethylguanosine synthase homolog (S. cerevisiae)	-	HPRD,BioGRID	11517327
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10847592 \|11158331
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10823961 \|11158331 \|11773444
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	Affinity Capture-MS Co-purification	BioGRID	12482968
TUBB	M40 \| MGC117247 \| MGC16435 \| OK/SW-cl.56 \| TUBB1 \| TUBB5	tubulin, beta	Affinity Capture-MS Co-purification	BioGRID	12482968
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Affinity Capture-MS	BioGRID	10823961 \|12519782
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	Affinity Capture-MS Reconstituted Complex	BioGRID	10823961 \|12519782
ZNF335	NIF1 \| NIF2	zinc finger protein 335	-	HPRD,BioGRID	12215545

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_AR_PATHWAY	61	46	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	36	27	All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	104	72	All SZGR genes in this pathway
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION	24	17	All SZGR genes in this pathway
REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	24	16	All SZGR genes in this pathway
REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA	23	16	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	168	115	All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK	53	40	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	72	53	All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN	309	191	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP	329	196	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP	127	79	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_UP	11	8	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES	147	87	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON	31	18	All SZGR genes in this pathway
NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER	94	60	All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN	76	57	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM	32	15	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN	271	175	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED	351	238	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway
IKEDA_MIR133_TARGETS_UP	43	27	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	293	299	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	293	299	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-224	66	72	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-23	482	489	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	482	489	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	482	488	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-369-3p	410	416	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	410	416	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-377	347	354	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-410	412	418	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-486	291	297	m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-493-5p	477	483	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.