Gene Page: PARC

Summary
GeneID  23113
Symbol  PARC
Synonyms  DKFZp686G1042|DKFZp686P2024|H7AP1|RP3-330M21.2
Description  p53-associated parkin-like cytoplasmic protein
See related  MIM:607489|Ensembl:ENSG00000112659|HPRD:06317|
Locus tag  -
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MGA0.970.97
BIRC60.970.97
C10orf180.960.96
NSD10.960.95
UBR50.960.96
TUG10.950.96
MED10.950.96
SBF20.950.95
ZNF4450.950.94
CLASP10.950.95
Top 10 negatively co-expressed genes
AF347015.31-0.71-0.83
MT-CO2-0.70-0.84
IFI27-0.70-0.83
FXYD1-0.70-0.81
C5orf53-0.69-0.72
HIGD1B-0.68-0.84
AF347015.27-0.68-0.79
S100B-0.68-0.77
AF347015.33-0.67-0.78
HLA-F-0.67-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI18230339 
GO:0005524ATP bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0031625ubiquitin protein ligase bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0030071regulation of mitotic metaphase/anaphase transitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005680anaphase-promoting complexIEA-
GO:0005737cytoplasmIEA-
GO:0031461cullin-RING ubiquitin ligase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PARCDKFZp686G1042 | DKFZp686P2024 | H7AP1 | RP3-330M21.2p53-associated parkin-like cytoplasmic proteinBiochemical ActivityBioGRID12526791 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID12526791 
Parc interacts with p53BIND15558054 
UBE2G2UBC7ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)-HPRD10521492 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID10521492 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCHWAB_TARGETS_OF_BMYB_POLYMORPHIC_VARIANTS_DN 1712All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_DN 5024All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP 11868All SZGR genes in this pathway


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