Gene Page: FLNB

Summary
GeneID  2317
Symbol  FLNB
Synonyms  ABP-278|AOI|DKFZp686A1668|DKFZp686O033|FH1|FLN1L|LRS1|SCT|TABP|TAP
Description  filamin B, beta (actin binding protein 278)
See related  HGNC:3755|MIM:603381|Ensembl:ENSG00000136068|HPRD:04543|
Locus tag  -
Gene type  protein-coding
Map location  3p14.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingNAS8327473 
GO:0005515protein bindingIPI10676904 |16076904 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0007165signal transductionTAS8327473 
GO:0007016cytoskeletal anchoring at plasma membraneTAS9694715 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0030036actin cytoskeleton organizationTAS8327473 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001725stress fiberIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0016021integral to membraneNAS8327473 
GO:0005925focal adhesionIEA-
GO:0015629actin cytoskeletonTAS9651345 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FBLIM1CAL | DKFZp434G171 | FBLP-1 | FBLP1 | RP11-169K16.5filamin binding LIM protein 1-HPRD,BioGRID12496242 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD,BioGRID12393796 
GP1BABSS | CD42B | CD42b-alpha | GP1B | MGC34595glycoprotein Ib (platelet), alpha polypeptide-HPRD,BioGRID9651345 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD,BioGRID11807098 
ITGB3CD61 | GP3A | GPIIIaintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Two-hybridBioGRID11807098 
ITGB6-integrin, beta 6Two-hybridBioGRID11807098 
NPHP1FLJ97602 | JBTS4 | NPH1 | SLSN1nephronophthisis 1 (juvenile)-HPRD,BioGRID12006559 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Reconstituted Complex
Two-hybrid		BioGRID9437013 
PSEN2AD3L | AD4 | PS2 | STM2presenilin 2 (Alzheimer disease 4)-HPRD,BioGRID9437013 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptor-HPRD,BioGRID8327473 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
LOPEZ_MESOTELIOMA_SURVIVAL_TIME_UP 148All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP 6339All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_WORST_VS_BEST_UP 1410All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN 3123All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_UP 2719All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_LB_UP 4828All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8 7256All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
KANG_FLUOROURACIL_RESISTANCE_DN 1610All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
MASSARWEH_RESPONSE_TO_ESTRADIOL 6147All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_DN 7849All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION 2214All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
VALK_AML_CLUSTER_10 3322All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_DN 168All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-145142214291A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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