Gene Page: SYNE1

Summary
GeneID  23345
Symbol  SYNE1
Synonyms  8B|CPG2|DKFZp781J13156|FLJ30878|FLJ41140|KIAA0796|KIAA1262|KIAA1756|MYNE1|SCAR8
Description  spectrin repeat containing, nuclear envelope 1
See related  HGNC:17089|MIM:608441|Ensembl:ENSG00000131018|HPRD:09762|
Locus tag  RP1-130E4.2
Gene type  protein-coding
Map location  6q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6157 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIDA12408964 
GO:0003779actin bindingIEA-
GO:0005515protein bindingIEA-
GO:0005521lamin bindingIPI11801724 
GO:0005198structural molecule activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008219cell deathIEA-
GO:0007030Golgi organizationIDA12808039 
GO:0006997nucleus organizationNAS11792814 
GO:0042692muscle cell differentiationIDA11792814 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIDASynap, Neurotransmitter (GO term level: 5)10878022 
GO:0005794Golgi apparatusIDA12808039 
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005635nuclear envelopeIDA11792814 
GO:0005635nuclear envelopeIEA-
GO:0005640nuclear outer membraneIEA-
GO:0005737cytoplasmIEA-
GO:0016021integral to membraneIDA11792814 
GO:0016021integral to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD12408964 
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunitCAPN1 interacts with SYNE1.BIND12358155 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1-HPRD,BioGRID12812986 
EMDEDMD | LEMD5 | STAemerin-HPRD,BioGRID12163176 
LMNACDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1lamin A/C-HPRD,BioGRID11801724 
MUSKMGC126323 | MGC126324muscle, skeletal, receptor tyrosine kinase-HPRD,BioGRID10878022 
SYNE18B | CPG2 | DKFZp781J13156 | FLJ30878 | FLJ41140 | KIAA0796 | KIAA1262 | KIAA1756 | MYNE1 | SCAR8spectrin repeat containing, nuclear envelope 1-HPRD,BioGRID12163176 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_MEIOTIC_SYNAPSIS 7357All SZGR genes in this pathway
WINTER_HYPOXIA_DN 5230All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN 12073All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_2 4231All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_UP 5030All SZGR genes in this pathway
NAKAJIMA_EOSINOPHIL 3020All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_UP 4426All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497362368m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-181644650m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-236316371Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-29359365m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-369-3p7297351Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374729735m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-493-5p679685m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-5436456521A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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