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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: RYBP

Summary

GeneID

23429

Symbol

RYBP

Synonyms

AAP1|DEDAF|YEAF1

Description

RING1 and YY1 binding protein

Locus tag

Gene type

protein-coding

Map location

3p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.04359

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.04047

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

GNG13

0.89

0.66

CPNE9

0.86

0.74

WNT2

0.86

0.62

RDH12

0.85

0.64

DPYS

0.83

0.60

FAM19A4

0.83

0.62

CASQ2

0.83

0.52

NPL

0.83

0.46

RGS16

0.82

0.30

CCDC136

0.82

0.36

Top 10 negatively co-expressed genes

WDR86

-0.37

-0.55

EMID1

-0.31

-0.47

PVRL2

-0.30

-0.55

PLEKHO1

-0.30

-0.43

OLFM2

-0.29

-0.46

AC022098.2

-0.29

-0.46

NR2C2AP

-0.28

-0.44

MARCKSL1

-0.28

-0.54

TUBB2B

-0.28

-0.62

SHF

-0.28

-0.42

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

IEA

GO:0003714

transcription corepressor activity

TAS

10369680

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

TAS

10369680

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0006915

apoptosis

IEA

GO:0007275

multicellular organismal development

TAS

10369680

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Far Western Reconstituted Complex Two-hybrid	BioGRID	8943360
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11395500
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD	11395500
CBX2	CDCA6 \| M33 \| MGC10561	chromobox homolog 2 (Pc class homolog, Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	10369680
E2F2	E2F-2	E2F transcription factor 2	E2F2 interacts with RYBP.	BIND	12411495
E2F2	E2F-2	E2F transcription factor 2	Affinity Capture-Western Two-hybrid	BioGRID	12411495
E2F3	DKFZp686C18211 \| E2F-3 \| KIAA0075 \| MGC104598	E2F transcription factor 3	Affinity Capture-Western Two-hybrid	BioGRID	12411495
E2F3	DKFZp686C18211 \| E2F-3 \| KIAA0075 \| MGC104598	E2F transcription factor 3	E2F3 interacts with RYBP.	BIND	12411495
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	Two-hybrid	BioGRID	12411495
E2F6	E2F-6 \| MGC111545	E2F transcription factor 6	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	11171983 \|12411495
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	Affinity Capture-Western	BioGRID	11395500
RING1	RING1A \| RNF1	ring finger protein 1	-	HPRD,BioGRID	10369680
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD,BioGRID	10369680

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_E2F_PATHWAY	74	48	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	634	384	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN	526	357	All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_DN	38	25	All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN	145	91	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP	136	80	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP	276	165	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP	139	83	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP	341	197	All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN	240	171	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN	167	100	All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_DN	58	35	All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP	58	40	All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP	164	122	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_120_MCF10A	65	44	All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_DN	24	15	All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN	43	31	All SZGR genes in this pathway
WU_HBX_TARGETS_2_DN	16	11	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	314	201	All SZGR genes in this pathway
WU_HBX_TARGETS_1_DN	23	14	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN	123	86	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D2	41	30	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL	311	205	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP	223	132	All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE	200	115	All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12	317	177	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP	40	30	All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES	70	46	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A	770	480	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4	227	149	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY	1839	928	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	2133	2139	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-10	32	38	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	32	38	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	64	70	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	64	70	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124.1	3099	3105	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	3099	3105	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	3099	3105	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	2173	2180	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	2173	2180	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	546	553	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	2277	2283	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135	2194	2200	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	2194	2200	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-136	3241	3247	m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-141/200a	2864	2871	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2864	2871	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	3695	3701	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-148/152	2278	2284	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497	65	71	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	3694	3700	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-19	3	9	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	3	9	1A	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-208	3583	3589	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-217	2968	2974	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-218	2859	2865	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-219	228	234	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	724	730	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	724	730	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-27	547	554	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	547	554	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	534	540	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-323	724	730	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-5p	1972	1979	1A,m8	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU
miR-330	812	818	1A	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-335	183	189	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-376	597	604	1A,m8	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
				hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
				hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
				hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
				hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
				hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-381	3457	3464	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	3457	3464	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	493	499	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-485-3p	3285	3291	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-488	3035	3041	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-493-5p	304	310	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	3407	3413	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
				hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
				hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	2355	2362	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-499	3583	3589	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-499	3583	3589	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-7	433	439	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	2027	2033	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.