Gene Page: GABRA1

Summary
GeneID  2554
Symbol  GABRA1
Synonyms  ECA4|EJM
Description  gamma-aminobutyric acid (GABA) A receptor, alpha 1
See related  HGNC:4075|MIM:137160|Ensembl:ENSG00000022355|HPRD:00662|
Locus tag  -
Gene type  protein-coding
Map location  5q34-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3066 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NEB0.410.40
CCDC1360.400.35
CACNA1G0.390.33
CAPRIN20.390.39
DQX10.380.27
GRM10.380.36
GBA20.380.41
FBXO100.370.41
IL21R0.370.21
TMEM41A0.370.28
Top 10 negatively co-expressed genes
GNG11-0.27-0.34
PRKCDBP-0.25-0.25
CLEC3B-0.25-0.29
METRN-0.24-0.24
MYL12A-0.24-0.27
AL138743.2-0.24-0.25
CCDC72-0.23-0.30
VAMP5-0.23-0.25
RPL35-0.23-0.25
IGFBP7-0.23-0.25
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0004890GABA-A receptor activityTASGABA (GO term level: 7)2465923 
GO:0005515protein bindingIEA-
GO:0005254chloride channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0031404chloride ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007214gamma-aminobutyric acid signaling pathwayTASGABA, Neurotransmitter (GO term level: 8)2465923 
GO:0006821chloride transportIEA-
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2465923 
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DRD4D4DRdopamine receptor D4-HPRD10050966 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, deltaAffinity Capture-WesternBioGRID12091471 
PRKCGMGC57564 | PKC-gamma | PKCC | PKCG | SCA14protein kinase C, gamma-HPRD,BioGRID12091471 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
BIOCARTA_GABA_PATHWAY 1010All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_GABA_A_RECEPTOR_ACTIVATION 1212All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_ION_CHANNEL_TRANSPORT 5542All SZGR genes in this pathway
REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT 2121All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP 181112All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137148314891Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-14653591Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-15/16/195/424/497179117971Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1819139201A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-203.1192119281A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-21610151021m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-221/222140114081A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-3209449501Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-34b187718831Ahsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-376c150415101Ahsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-4109269321Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-493-5p14321438m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-49699910051Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-503179117971Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-5059109161Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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