Gene Page: GC

Summary
GeneID  2638
Symbol  GC
Synonyms  DBP|DBP/GC|VDBG|VDBP
Description  group-specific component (vitamin D binding protein)
See related  HGNC:4187|MIM:139200|Ensembl:ENSG00000145321|HPRD:00749|
Locus tag  -
Gene type  protein-coding
Map location  4q12-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIPI12119014 
GO:0005499vitamin D bindingIEA-
GO:0005499vitamin D bindingTAS1696927 
GO:0005515protein bindingIPI12119014 
GO:0051183vitamin transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006810transportIEA-
GO:0042359vitamin D metabolic processIEA-
GO:0051180vitamin transportTAS1696927 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA18029348 
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceIEA-
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscleCo-crystal StructureBioGRID12554937 
-HPRD12119014 
ACTA2AAT6 | ACTSAactin, alpha 2, smooth muscle, aorta-HPRD12119014 
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD,BioGRID12452439 |12554937 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD,BioGRID2824652 
CDC73C1orf28 | FLJ23316 | HPT-JT | HRPT2cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)Two-hybridBioGRID16169070 
CUBNFLJ90055 | FLJ90747 | IFCR | MGA1 | gp280cubilin (intrinsic factor-cobalamin receptor)-HPRD,BioGRID11717447 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)-HPRD,BioGRID12048248 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID11717447 
SERF24F5REL | FAM2C | FLJ20431 | FLJ37527 | FLJ38557 | H4F5rel | HsT17089 | MGC48826small EDRK-rich factor 2Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 3523All SZGR genes in this pathway
REACTOME_STEROID_HORMONES 2921All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
ROVERSI_GLIOMA_LOH_REGIONS 4430All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
YOSHIOKA_LIVER_CANCER_EARLY_RECURRENCE_DN 6531All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_UP 5638All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway


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