Gene Page: GCLC

Summary
GeneID  2729
Symbol  GCLC
Synonyms  GCS|GLCL|GLCLC
Description  glutamate-cysteine ligase, catalytic subunit
See related  HGNC:4311|MIM:606857|Ensembl:ENSG00000001084|HPRD:06032|
Locus tag  -
Gene type  protein-coding
Map location  6p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GLUD20.950.95
GPC50.910.88
SUCLG20.900.88
GJA10.900.86
S1PR10.890.81
PLSCR40.890.89
ITM2C0.870.88
ADD30.860.88
KCNJ160.860.83
NT5E0.850.86
Top 10 negatively co-expressed genes
RTF1-0.53-0.57
CCAR1-0.50-0.59
DPF1-0.49-0.48
MPP3-0.49-0.49
GMIP-0.49-0.47
RP9-0.49-0.58
ZNF821-0.49-0.48
PHF14-0.49-0.56
AC011491.1-0.48-0.56
CHD3-0.48-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016595glutamate bindingIDAglutamate (GO term level: 5)9841880 
GO:0004357glutamate-cysteine ligase activityIDAglutamate (GO term level: 6)8104187 |11972604 
GO:0004357glutamate-cysteine ligase activityIMPglutamate (GO term level: 6)16183645 
GO:0000287magnesium ion bindingIDA24639 
GO:0016874ligase activityIEA-
GO:0050662coenzyme bindingIPI9675072 |9841880 
GO:0046982protein heterodimerization activityIEA-
GO:0043531ADP bindingIDA24639 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006536glutamate metabolic processIDAglutamate (GO term level: 8)2294991 |12663448 
GO:0006534cysteine metabolic processIDA2294991 
GO:0019852L-ascorbic acid metabolic processIEA-
GO:0009410response to xenobiotic stimulusIEA-
GO:0009408response to heatIDA8104187 
GO:0009725response to hormone stimulusIDA8104187 
GO:0006750glutathione biosynthetic processIDA8104187 |10395918 
GO:0006750glutathione biosynthetic processIMP12663448 
GO:0006979response to oxidative stressIDA10395918 |11972604 
GO:0006916anti-apoptosisIDA10439045 
GO:0016481negative regulation of transcriptionIDA10439045 
GO:0031397negative regulation of protein ubiquitinationIEA-
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEA-
GO:0050880regulation of blood vessel sizeIMP12598062 
GO:0046685response to arsenicIEA-
GO:0045454cell redox homeostasisIDA10439045 
GO:0051900regulation of mitochondrial depolarizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0017109glutamate-cysteine ligase complexIEAglutamate (GO term level: 8)-
GO:0005829cytosolIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLUTATHIONE_METABOLISM 5034All SZGR genes in this pathway
REACTOME_SULFUR_AMINO_ACID_METABOLISM 2417All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_GLUTATHIONE_CONJUGATION 2313All SZGR genes in this pathway
REACTOME_PHASE_II_CONJUGATION 7042All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP 3225All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN 6244All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP 11069All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2 5439All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
SINGH_NFE2L2_TARGETS 1512All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
ITO_PTTG1_TARGETS_UP 129All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_DN 4026All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN 5639All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063323381Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-185195261A,m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-433-3p100210091A,m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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