Gene Page: GLRA1

Summary
GeneID  2741
Symbol  GLRA1
Synonyms  MGC138878|MGC138879|STHE
Description  glycine receptor, alpha 1
See related  HGNC:4326|MIM:138491|Ensembl:ENSG00000145888|HPRD:00719|
Locus tag  -
Gene type  protein-coding
Map location  5q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0004890GABA-A receptor activityIEAGABA (GO term level: 7)-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI11929858 
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0016934extracellular-glycine-gated chloride channel activityIDA2155780 |8137830 
GO:0016594glycine bindingIDA2155780 |15748848 
GO:0030977taurine bindingIDA15748848 
GO:0031404chloride ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051970negative regulation of transmission of nerve impulseIMPneuron (GO term level: 7)11973623 
GO:0060080regulation of inhibitory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0060012synaptic transmission, glycinergicIEAneuron, Synap, Neurotransmitter (GO term level: 8)-
GO:0007218neuropeptide signaling pathwayIDANeurotransmitter (GO term level: 8)2155780 
GO:0002087regulation of respiratory gaseous exchange by neurological processIEABrain (GO term level: 6)-
GO:0001508regulation of action potentialIEA-
GO:0001964startle responseIMP8298642 |11973623 
GO:0007628adult walking behaviorIEA-
GO:0007601visual perceptionIEA-
GO:0006821chloride transportIDA8137830 
GO:0006811ion transportIDA2155780 
GO:0006936muscle contractionIMP11973623 
GO:0007340acrosome reactionIEA-
GO:0060013righting reflexIEA-
GO:0050884neuromuscular process controlling postureIEA-
GO:0043576regulation of respiratory gaseous exchangeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005622intracellularIEA-
GO:0005624membrane fractionIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIDA7506679 
GO:0005887integral to plasma membraneIMP11973623 
GO:0005887integral to plasma membraneNAS2155780 
GO:0030054cell junctionIEA-
GO:0043231intracellular membrane-bounded organelleIDA7506679 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_ION_CHANNEL_TRANSPORT 5542All SZGR genes in this pathway
REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT 2121All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
LEIN_MEDULLA_MARKERS 8148All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15025311Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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