Gene Page: GNAS

Summary
GeneID  2778
Symbol  GNAS
Synonyms  AHO|C20orf45|GNAS1|GPSA|GSA|GSP|MGC33735|PHP1A|PHP1B|POH|dJ309F20.1.1|dJ806M20.3.3
Description  GNAS complex locus
See related  HGNC:4392|MIM:139320|Ensembl:ENSG00000087460|Ensembl:ENSG00000213705|HPRD:00761|
Locus tag  RP4-543J19.4
Gene type  protein-coding
Map location  20q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0003674molecular_functionND-
GO:0003924GTPase activityNAS1716359 
GO:0003924GTPase activityTAS9159128 
GO:0005525GTP bindingIEA-
GO:0005525GTP bindingNAS-
GO:0019001guanyl nucleotide bindingIEA-
GO:0042802identical protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007191dopamine receptor, adenylate cyclase activating pathwayIEAdopamine (GO term level: 12)-
GO:0001958endochondral ossificationIEA-
GO:0007190activation of adenylate cyclase activityTAS9159128 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayNAS1716359 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0006112energy reserve metabolic processIEA-
GO:0007165signal transductionIEA-
GO:0007165signal transductionNAS-
GO:0009306protein secretionNAS10729789 
GO:0009755hormone-mediated signalingEXP12626323 
GO:0009791post-embryonic developmentIEA-
GO:0007608sensory perception of smellTAS3018580 
GO:0007565female pregnancyNAS10729789 
GO:0006605protein targetingIEA-
GO:0042493response to drugIEA-
GO:0051216cartilage developmentIEA-
GO:0040032post-embryonic body morphogenesisIEA-
GO:0048701embryonic cranial skeleton morphogenesisIEA-
GO:0035116embryonic hindlimb morphogenesisIEA-
GO:0046907intracellular transportNAS7997272 
GO:0045669positive regulation of osteoblast differentiationIEA-
GO:0045672positive regulation of osteoclast differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005834heterotrimeric G-protein complexNAS1716359 
GO:0005834heterotrimeric G-protein complexTAS9159128 
GO:0005576extracellular regionNAS-
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmIDA11256614 
GO:0005886plasma membraneIEA-
GO:0005886plasma membraneNAS-
GO:0005886plasma membraneTAS9727013 
GO:0031224intrinsic to membraneIDA7997272 
GO:0032588trans-Golgi network membraneIDA7997272 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADCY2AC2 | FLJ16822 | FLJ45092 | HBAC2 | KIAA1060 | MGC133314adenylate cyclase 2 (brain)-HPRD9268375 
ADCY5AC5adenylate cyclase 5-HPRD9268375 
ADCY6AC6 | DKFZp779F075 | KIAA0422adenylate cyclase 6-HPRD,BioGRID9228084 
ADORA1RDC7adenosine A1 receptor-HPRD10521440 
ADRB3BETA3ARadrenergic, beta-3-, receptor-HPRD8011597 
AVPR2ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2Rarginine vasopressin receptor 2-HPRD8621513 
CAV3LGMD1C | LQT9 | MGC126100 | MGC126101 | MGC126129 | VIP-21 | VIP21caveolin 3-HPRD,BioGRID7797570 
CRHR1CRF-R | CRF1 | CRFR1 | CRH-R1h | CRHR | CRHR1fcorticotropin releasing hormone receptor 1-HPRD,BioGRID10598591 
FSCN1FLJ38511 | SNL | p55fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)Affinity Capture-MSBioGRID17353931 
GCGRGGR | MGC138246glucagon receptor-HPRD1908089 
GNB1-guanine nucleotide binding protein (G protein), beta polypeptide 1G-beta-1 interacts with G-alpha-s.BIND15782186 
-HPRD11294873 
HTR65-HT6 | 5-HT6R5-hydroxytryptamine (serotonin) receptor 6-HPRD11916537 
LHCGRFLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-Rluteinizing hormone/choriogonadotropin receptor-HPRD10493819 
PAICSADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAISphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseAffinity Capture-MSBioGRID17353931 
PLEKHB1KPL1 | PHR1 | PHRET1pleckstrin homology domain containing, family B (evectins) member 1-HPRD10585447 
PTGDRAS1 | ASRT1 | DP | DP1 | MGC49004prostaglandin D2 receptor (DP)-HPRD,BioGRID12672054 
PTGIRIP | MGC102830 | PRIPRprostaglandin I2 (prostacyclin) receptor (IP)-HPRD,BioGRID12488443 
RGS2G0S8regulator of G-protein signaling 2, 24kDa-HPRD,BioGRID9794454 
RIC8AMGC104517 | MGC131931 | MGC148073 | MGC148074 | RIC8 | synembrynresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)-HPRD,BioGRID12652642 
RIC8BFLJ10620 | MGC39476 | RIC8 | hSynresistance to inhibitors of cholinesterase 8 homolog B (C. elegans)-HPRD12652642 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)Affinity Capture-MSBioGRID17353931 
SHMT2GLYA | SHMTserine hydroxymethyltransferase 2 (mitochondrial)Affinity Capture-MSBioGRID17353931 
SNX13KIAA0713 | RGS-PX1sorting nexin 13-HPRD,BioGRID11729322 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptor-HPRD9525885 
TTC1FLJ46404 | TPR1tetratricopeptide repeat domain 1G-alpha-s-Short interacts with TPR1.BIND12748287 
-HPRD,BioGRID12748287 
G-alpha-s-Long interacts with TPR1.BIND12748287 
VIPR1FLJ41949 | HVR1 | II | PACAP-R-2 | RDC1 | VAPC1 | VIPR | VIRG | VPAC1 | VPCAP1Rvasoactive intestinal peptide receptor 1-HPRD,BioGRID11812005 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_TASTE_TRANSDUCTION 5228All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 4430All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION 5632All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_AGPCR_PATHWAY 1312All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_GCR_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_CFTR_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_PLCE_PATHWAY 1210All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_BARRESTIN_PATHWAY 108All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 3423All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 3322All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 5134All SZGR genes in this pathway
REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR 1911All SZGR genes in this pathway
REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 4430All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
TOMIDA_METASTASIS_UP 2613All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP 6045All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_8 3628All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 14976All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP 4730All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_UP 9864All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP 7149All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_UP 4025All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP 5325All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_DN 1811All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP 4935All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway


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