Gene Page: GNAZ

Summary
GeneID  2781
Symbol  GNAZ
Synonyms  -
Description  guanine nucleotide binding protein (G protein), alpha z polypeptide
See related  HGNC:4395|MIM:139160|Ensembl:ENSG00000128266|HPRD:00746|
Locus tag  -
Gene type  protein-coding
Map location  22q11.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2005 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC073995.10.590.47
ANAPC40.560.60
GRB140.550.59
AC027807.20.540.43
KCNMB30.540.37
AC087071.10.540.48
AC022692.20.540.39
SNHG120.530.44
DNAJC20.530.63
MTERFD30.510.53
Top 10 negatively co-expressed genes
CASKIN2-0.49-0.51
A4GALT-0.46-0.52
SLC2A1-0.46-0.46
HLA-E-0.45-0.51
SLC9A3R1-0.45-0.54
MAPKAPK3-0.45-0.53
MOCS1-0.45-0.46
PPP1R13L-0.44-0.52
ALDH2-0.44-0.49
FOXO4-0.44-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005057receptor signaling protein activityTAS2456569 
GO:0003924GTPase activityTAS2117645 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS3129724 
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005635nuclear envelopeTAS2117645 
GO:0005737cytoplasmIDA18029348 
GO:0005783endoplasmic reticulumTAS2117645 
GO:0005886plasma membraneTAS3129724 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DRD2D2DR | D2Rdopamine receptor D2-HPRD9166747 
DRD5DBDR | DRD1B | DRD1L2 | MGC10601dopamine receptor D5-HPRD9603210 
EYA2EAB1 | MGC10614eyes absent homolog 2 (Drosophila)-HPRD,BioGRID10906137 
OPRD1OPRDopioid receptor, delta 1-HPRD9166747 
RAP1GAPKIAA0474 | RAP1GA1 | Rap1GAP1 | rap1GAPIIRAP1 GTPase activating protein-HPRD,BioGRID10593970 
RGS10-regulator of G-protein signaling 10Affinity Capture-WesternBioGRID8774883 
RGS19GAIP | RGSGAIPregulator of G-protein signaling 19-HPRD,BioGRID8986788 
RGS20RGSZ1 | ZGAP1regulator of G-protein signaling 20-HPRD9748279|12414994 
Biochemical Activity
Co-localization		BioGRID9748279 |12414994 
RGS7-regulator of G-protein signaling 7-HPRD,BioGRID10092682 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY 1411All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
TERAMOTO_OPN_TARGETS_CLUSTER_4 138All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_POOR_PROGNOSIS 5530All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN 14690All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p637643m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-186858864m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-27126012661Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-3318086m8hsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-4506376431Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4521531601A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-542-3p2732801A,m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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