Gene Page: DLL1

Summary
GeneID  28514
Symbol  DLL1
Synonyms  DELTA1|DL1|Delta
Description  delta-like 1 (Drosophila)
See related  HGNC:2908|MIM:606582|Ensembl:ENSG00000198719|HPRD:05957|
Locus tag  -
Gene type  protein-coding
Map location  6q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005112Notch bindingIPI10079256 |11823422 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001757somite specificationIEA-
GO:0001709cell fate determinationNAS11581320 
GO:0007154cell communicationIEA-
GO:0007386compartment specificationIEA-
GO:0007368determination of left/right symmetryIEA-
GO:0007219Notch signaling pathwayNAS10079256 
GO:0007275multicellular organismal developmentNAS-
GO:0030155regulation of cell adhesionTAS11912004 
GO:0030097hemopoiesisNAS11581320 
GO:0045608negative regulation of auditory receptor cell differentiationIEA-
GO:0045596negative regulation of cell differentiationIEA-
GO:0048839inner ear developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS11823422 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS10079256 
GO:0031410cytoplasmic vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1Delta1 interacts with MAGI-1.BIND15509766 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)Reconstituted ComplexBioGRID11006133 
NOTCH2AGS2 | hN2Notch homolog 2 (Drosophila)-HPRD,BioGRID10958687 
NOTCH3CADASIL | CASILNotch homolog 3 (Drosophila)-HPRD,BioGRID11006133 |12482954 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH4 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH2 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH3 1210All SZGR genes in this pathway
REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 128All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
FUKUSHIMA_TNFSF11_TARGETS 1614All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_UP 14675All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1077379m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-130/3012202271A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-149324330m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/4977480m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-2141071131Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-243233291Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-34/449293299m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b357363m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-36252591A,m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-3635795851Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-376c532538m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-3815515571Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-493-5p5125191A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4956086141Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-5435845901Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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