Gene Page: GPX1

Summary
GeneID  2876
Symbol  GPX1
Synonyms  GSHPX1|MGC14399|MGC88245
Description  glutathione peroxidase 1
See related  HGNC:4553|MIM:138320|Ensembl:ENSG00000197582|HPRD:11749|
Locus tag  -
Gene type  protein-coding
Map location  3p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SNX100.910.91
OLFM30.900.85
RAB6B0.890.88
MOAP10.880.90
MAPK90.860.92
REEP50.860.87
ATP1B10.860.92
WBSCR170.850.88
ZMAT40.850.82
TPD520.850.85
Top 10 negatively co-expressed genes
NME4-0.48-0.60
SIGIRR-0.47-0.56
RPL28-0.43-0.51
EMX2-0.43-0.57
BCL7C-0.43-0.52
RAB13-0.42-0.53
RPL23A-0.42-0.45
SH2D2A-0.42-0.44
GRTP1-0.41-0.43
EFEMP2-0.41-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004602glutathione peroxidase activityEXP8428933 
GO:0004602glutathione peroxidase activityIEA-
GO:0008430selenium bindingIEA-
GO:0008539proteasome inhibitor activityIDA12751788 
GO:0017124SH3 domain bindingIPI12893824 
GO:0016491oxidoreductase activityIEA-
GO:0043295glutathione bindingIC12829378 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001836release of cytochrome c from mitochondriaIMP12221075 
GO:0008631induction of apoptosis by oxidative stressIEA-
GO:0009650UV protectionIMP17097614 
GO:0010269response to selenium ionIMP12810669 
GO:0006749glutathione metabolic processIDA12829378 
GO:0006979response to oxidative stressIEA-
GO:0006916anti-apoptosisIMP12221075 
GO:0033599regulation of mammary gland epithelial cell proliferationIMP16945136 
GO:0042744hydrogen peroxide catabolic processIEA-
GO:0040029regulation of gene expression, epigeneticIDA16132718 
GO:0043154negative regulation of caspase activityIMP12221075 
GO:0055114oxidation reductionIEA-
GO:0060047heart contractionIMP14573732 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP8428933 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID12893824 
ABL2ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)-HPRD12893824 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLUTATHIONE_METABOLISM 5034All SZGR genes in this pathway
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
BIOCARTA_FREE_PATHWAY 107All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
REACTOME_METABOLISM_OF_NUCLEOTIDES 7245All SZGR genes in this pathway
REACTOME_PURINE_CATABOLISM 106All SZGR genes in this pathway
REACTOME_PURINE_METABOLISM 3324All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
HOUSTIS_ROS 3629All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FERRANDO_LYL1_NEIGHBORS 1512All SZGR genes in this pathway
ASTIER_INTEGRIN_SIGNALING 5944All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_UP 8655All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
MOOTHA_ROS 77All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP 3225All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MS_DN 4624All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN 14690All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway


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