Gene Page: GRIA1

Summary
GeneID  2890
Symbol  GRIA1
Synonyms  GLUH1|GLUR1|GLURA|HBGR1|MGC133252
Description  glutamate receptor, ionotropic, AMPA 1
See related  HGNC:4571|MIM:138248|Ensembl:ENSG00000155511|HPRD:00695|
Locus tag  -
Gene type  protein-coding
Map location  5q33|5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4005 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PORCN0.900.87
C3orf390.890.88
SCYL10.890.87
FAM127A0.880.86
ATP6AP10.880.87
RNF1230.870.83
ACP20.860.85
SLC45A10.860.87
CDIPT0.860.86
C17orf280.850.82
Top 10 negatively co-expressed genes
AF347015.21-0.58-0.44
AF347015.18-0.56-0.48
NSBP1-0.56-0.55
AL139819.3-0.53-0.51
MT-ATP8-0.52-0.42
AF347015.8-0.52-0.39
GNG11-0.52-0.45
MT-CO2-0.50-0.37
NOSTRIN-0.50-0.39
AF347015.31-0.50-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0015277kainate selective glutamate receptor activityTASglutamate (GO term level: 8)1311100 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)1311100 
GO:0007165signal transductionTAS1311100 
GO:0007616long-term memoryIEA-
GO:0006811ion transportIEA-
GO:0031623receptor internalizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS1311100 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNG2MGC138502 | MGC138504calcium channel, voltage-dependent, gamma subunit 2-HPRD,BioGRID11140673 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD10461883 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID9677374 |11567040 
EPB41L14.1N | DKFZp686H17242 | KIAA0338 | MGC11072erythrocyte membrane protein band 4.1-like 1-HPRD,BioGRID11050113 
EPB41L24.1-G | DKFZp781D1972 | DKFZp781H1755erythrocyte membrane protein band 4.1-like 2-HPRD,BioGRID11050113 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-WesternBioGRID10358037 
GRIA4GLUR4 | GLUR4C | GLURDglutamate receptor, ionotrophic, AMPA 4-HPRD,BioGRID9466455 
GRID2MGC117022 | MGC117023 | MGC117024glutamate receptor, ionotropic, delta 2Affinity Capture-WesternBioGRID12573530 
GluR1 interacts with GluR-delta-2BIND12573530 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2Affinity Capture-WesternBioGRID8288598 
-HPRD10358037 
GRIP1GRIPglutamate receptor interacting protein 1Reconstituted ComplexBioGRID11891216 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)-HPRD,BioGRID9069287 |9808458 
|11418862 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD10461883 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1-HPRD,BioGRID11891216 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)-HPRD,BioGRID11891216 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1-HPRD14614461 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 1611All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 1514All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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