Gene Page: PYCARD

Summary
GeneID  29108
Symbol  PYCARD
Synonyms  ASC|CARD5|MGC10332|TMS|TMS-1|TMS1
Description  PYD and CARD domain containing
See related  HGNC:16608|MIM:606838|Ensembl:ENSG00000103490|HPRD:06020|
Locus tag  -
Gene type  protein-coding
Map location  16p12-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12019269 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008656caspase activator activityNAS12019269 
GO:0032090Pyrin domain bindingIPI15030775 
GO:0042803protein homodimerization activityIDA15030775 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006917induction of apoptosisTAS10567338 
GO:0007165signal transductionNAS12019269 
GO:0006954inflammatory responseIEA-
GO:0006919caspase activationNAS12019269 
GO:0033209tumor necrosis factor-mediated signaling pathwayIDA12656673 
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA12656673 
GO:0050718positive regulation of interleukin-1 beta secretionIDA15030775 
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005576extracellular regionIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmNAS12019269 
GO:0008385IkappaB kinase complexTAS12656673 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD11967258 |12019269 
|12191486 
MEFVFMF | MEF | MGC126560 | MGC126586 | TRIM20Mediterranean fever-HPRD,BioGRID11498534 |12054656 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD,BioGRID11374873 
NLRP12CLR19.3 | FCAS2 | NALP12 | PAN6 | PYPAF7 | RNO | RNO2NLR family, pyrin domain containing 12-HPRD12019269 
NLRP3AGTAVPRL | AII | AII/AVP | AVP | C1orf7 | CIAS1 | CLR1.1 | FCAS | FCU | FLJ95925 | MWS | NALP3 | PYPAF1NLR family, pyrin domain containing 3PYPAF1 interacts with ASC.BIND11786556 
PRKAR1ACAR | CNC | CNC1 | DKFZp779L0468 | MGC17251 | PKR1 | PPNAD1 | PRKAR1 | TSE1protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)Two-hybridBioGRID16189514 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD10847592 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_THE_NLRP3_INFLAMMASOME 129All SZGR genes in this pathway
REACTOME_INFLAMMASOMES 1712All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
NOJIMA_SFRP2_TARGETS_DN 2518All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_UP 7432All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
ROSS_AML_WITH_MLL_FUSIONS 7845All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR 14984All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
PHESSE_TARGETS_OF_APC_AND_MBD2_UP 2014All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.