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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GRM1

Summary

GeneID

2911

Symbol

GRM1

Synonyms

GPRC1A|GRM1A|MGLUR1|MGLUR1A|mGlu1

Description

glutamate receptor, metabotropic 1

Locus tag

Gene type

protein-coding

Map location

6q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0024

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

TAS

neuron, Synap, Neurotransmitter (GO term level: 6)

9076744

GO:0007186

G-protein coupled receptor protein signaling pathway

IEA

GO:0007186

G-protein coupled receptor protein signaling pathway

TAS

7476890

GO:0007165

signal transduction

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016021

integral to membrane

IEA

GO:0005886

plasma membrane

IEA

GO:0005887

integral to plasma membrane

TAS

7476890

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADORA1	RDC7	adenosine A1 receptor	-	HPRD,BioGRID	11278325
GAPDH	G3PD \| GAPD \| MGC88685	glyceraldehyde-3-phosphate dehydrogenase	-	HPRD	9886087
GRM1	GPRC1A \| GRM1A \| MGLUR1 \| MGLUR1A \| mGlu1	glutamate receptor, metabotropic 1	-	HPRD,BioGRID	10349865 \|10945991
HOMER1	HOMER \| HOMER1A \| HOMER1B \| HOMER1C \| SYN47 \| Ves-1	homer homolog 1 (Drosophila)	-	HPRD	9069287
ITPR1	INSP3R1 \| IP3R \| IP3R1 \| SCA15 \| SCA16	inositol 1,4,5-triphosphate receptor, type 1	-	HPRD,BioGRID	9808459
TRPC1	HTRP-1 \| MGC133334 \| MGC133335 \| TRP1	transient receptor potential cation channel, subfamily C, member 1	Affinity Capture-Western	BioGRID	14614461
TUBB2A	TUBB \| TUBB2 \| dJ40E16.7	tubulin, beta 2A	-	HPRD	9886087

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	272	195	All SZGR genes in this pathway
KEGG_GAP_JUNCTION	90	68	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION	70	53	All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY	17	17	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	15	11	All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING	408	246	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN	261	183	All SZGR genes in this pathway
HILLION_HMGA1_TARGETS	90	71	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN	238	145	All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	435	318	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL	129	85	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1019	1025	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	151	158	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	151	158	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	151	157	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-139	1020	1026	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-144	1019	1025	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-204/211	245	252	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	245	252	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-218	261	268	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-221/222	1022	1028	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1022	1028	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-34b	2746	2752	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-381	1229	1236	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-539	2025	2032	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-96	949	955	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.