Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: SH3KBP1

Summary

GeneID

30011

Symbol

SH3KBP1

Synonyms

CIN85|GIG10|MIG18

Description

SH3-domain kinase binding protein 1

Locus tag

RP11-345L8.1

Gene type

protein-coding

Map location

Xp22.1-p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2206

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003674

molecular_function

GO:0005515

protein binding

IPI

12029088

GO:0017124

SH3 domain binding

IEA

GO:0016301

kinase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007267

cell-cell signaling

NAS

10679202

GO:0006915

apoptosis

IEA

GO:0006897

endocytosis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005829

cytosol

EXP

10567358 |11894095 |12218189
|15962011

GO:0005856

cytoskeleton

IEA

GO:0005634

nucleus

IDA

18029348

GO:0005730

nucleolus

IDA

18029348

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

EXP

16407834

GO:0030054

cell junction

IEA

GO:0031410

cytoplasmic vesicle

IEA

GO:0030659

cytoplasmic vesicle membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI2	ABI-2 \| ABI2B \| AIP-1 \| AblBP3 \| SSH3BP2 \| argBPIA \| argBPIB	abl interactor 2	-	HPRD,BioGRID	10858458
ARHGAP27	CAMGAP1 \| FLJ43547 \| MGC120624	Rho GTPase activating protein 27	-	HPRD,BioGRID	15147912
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DDEF1 (AMAP1) interacts with SH3KBP1 (CIN85).	BIND	15719014
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	DDEF2 (AMAP2) interacts with SH3KBP1 (CIN85).	BIND	15719014
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western	BioGRID	11071869
BLNK	BASH \| BLNK-S \| LY57 \| MGC111051 \| SLP-65 \| SLP65	B-cell linker	-	HPRD,BioGRID	11071869
CAPZA1	CAPPA1 \| CAPZ \| CAZ1	capping protein (actin filament) muscle Z-line, alpha 1	-	HPRD	12690097
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11894095
CBL	C-CBL \| CBL2 \| RNF55		CIN85 interacts with Cbl.	BIND	11894095
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	-	HPRD,BioGRID	12218189
CD2	SRBC \| T11	CD2 molecule	-	HPRD	12690097
			-	HPRD,BioGRID	9857189 \|12690097\|12690097
			SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2.	BIND	11152963
CLYBL	CLB \| bA134O15.1	citrate lyase beta like	Affinity Capture-Western	BioGRID	11894096
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11071869
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	11894095 \|12177062
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	9507006\|11152963
			SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2	BIND	11152963
			Reconstituted Complex	BioGRID	10921882 \|11152963
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Affinity Capture-Western	BioGRID	12177062
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	11894096
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	12218189
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD,BioGRID	12829691
PDCD6	ALG-2 \| FLJ46208 \| MGC111017 \| MGC119050 \| MGC9123 \| PEF1B	programmed cell death 6	-	HPRD,BioGRID	10858458
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	12177062
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	10921882
SH3GL1	CNSA1 \| EEN \| MGC111371 \| SH3D2B \| SH3P8	SH3-domain GRB2-like 1	Endophilin A2 interacts with CIN85. This interaction was modeled on a demonstrated interaction between endophilin A2 from an unspecified species and human CIN85.	BIND	11894096
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	-	HPRD,BioGRID	12218189
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	CIN85 interacts with endophilin A1. This interaction was modeled on a demonstrated interaction between human CIN85 and mouse endophilin A1.	BIND	11894095
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Endophilin A3 interacts with CIN85.	BIND	11894096
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	11894096
SH3GLB1	Bif-1 \| CGI-61 \| KIAA0491 \| dJ612B15.2	SH3-domain GRB2-like endophilin B1	Reconstituted Complex	BioGRID	11894096
SH3GLB2	KIAA1848 \| PP6569 \| PP9455	SH3-domain GRB2-like endophilin B2	Reconstituted Complex Two-hybrid	BioGRID	11894095 \|11894096
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	Affinity Capture-Western Two-hybrid	BioGRID	11071869 \|11894095
SHKBP1	PP203 \| Sb1	SH3KBP1 binding protein 1	-	HPRD,BioGRID	11152963
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	11071869
SYNJ1	INPP5G	synaptojanin 1	Affinity Capture-Western Far Western	BioGRID	12829691
TAF6	DKFZp781E21155 \| MGC:8964 \| TAF2E \| TAFII70 \| TAFII80 \| TAFII85	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	-	HPRD,BioGRID	12829691
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	-	HPRD,BioGRID	12829691

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY	13	10	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	29	24	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	126	90	All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION	25	14	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP	146	86	All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP	579	346	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN	455	304	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN	460	312	All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP	306	188	All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP	265	158	All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN	120	73	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN	378	231	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN	234	147	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP	191	128	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B	392	251	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN	165	104	All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP	268	157	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP	673	430	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP	602	364	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP	601	369	All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP	180	114	All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP	126	92	All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP	81	53	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3	162	80	All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3	128	68	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP	259	159	All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP	149	96	All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP	289	184	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	639	645	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	639	645	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-129-5p	977	983	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	977	983	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-142-5p	362	368	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-153	509	515	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	79	85	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-218	144	150	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-22	681	687	1A	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-26	2	8	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	2	8	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-33	997	1003	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	997	1003	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-410	579	585	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	962	968	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-448	962	968	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-450	977	983	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-542-3p	394	400	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	78	85	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.