Gene Page: HEXA

Summary
GeneID  3073
Symbol  HEXA
Synonyms  MGC99608|TSD
Description  hexosaminidase A (alpha polypeptide)
See related  HGNC:4878|MIM:606869|Ensembl:ENSG00000213614|HPRD:06040|
Locus tag  -
Gene type  protein-coding
Map location  15q23-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCBP10.960.95
WDR30.950.95
PAPOLG0.950.95
ZMYM40.950.95
KIAA14290.950.95
CAPRIN10.950.95
XRCC50.950.96
SMEK20.950.95
TAF20.950.95
EPRS0.950.95
Top 10 negatively co-expressed genes
MT-CO2-0.72-0.86
AF347015.31-0.71-0.85
IFI27-0.71-0.85
FXYD1-0.71-0.84
HLA-F-0.70-0.76
AF347015.33-0.70-0.83
AF347015.27-0.69-0.81
C5orf53-0.69-0.71
AC018755.7-0.68-0.73
MT-CYB-0.68-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004563beta-N-acetylhexosaminidase activityIEA-
GO:0016798hydrolase activity, acting on glycosyl bondsIEA-
GO:0043169cation bindingIEA-
GO:0046982protein heterodimerization activityIDA6230359 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042552myelinationIEAneuron, axon, Brain, oligodendrocyte (GO term level: 13)-
GO:0001501skeletal system developmentIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0008152metabolic processIEA-
GO:0019953sexual reproductionIEA-
GO:0007628adult walking behaviorIEA-
GO:0007626locomotory behaviorIEA-
GO:0007605sensory perception of soundIEA-
GO:0019915sequestering of lipidIEA-
GO:0007040lysosome organizationIEA-
GO:0006689ganglioside catabolic processIEA-
GO:0030203glycosaminoglycan metabolic processIEA-
GO:0050885neuromuscular process controlling balanceIEA-
GO:0050884neuromuscular process controlling postureIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005764lysosomeIEA-
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GM2ASAP-3GM2 ganglioside activator-HPRD,BioGRID9217013 
USP22KIAA1063 | USP3Lubiquitin specific peptidase 22Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OTHER_GLYCAN_DEGRADATION 1612All SZGR genes in this pathway
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 4430All SZGR genes in this pathway
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 2114All SZGR genes in this pathway
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES 1412All SZGR genes in this pathway
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES 159All SZGR genes in this pathway
KEGG_LYSOSOME 12183All SZGR genes in this pathway
REACTOME_GLYCOSPHINGOLIPID_METABOLISM 3822All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_CS_DS_DEGRADATION 129All SZGR genes in this pathway
REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION 107All SZGR genes in this pathway
REACTOME_HYALURONAN_METABOLISM 147All SZGR genes in this pathway
REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 4933All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM 3021All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_DEGRADATION 117All SZGR genes in this pathway
REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 11169All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_METABOLISM 6940All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN 14383All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LAMB_CCND1_TARGETS 1914All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
APPEL_IMATINIB_RESPONSE 3322All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP 4533All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP 6543All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway


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