Gene Page: HEXB

Summary
GeneID  3074
Symbol  HEXB
Synonyms  ENC-1AS
Description  hexosaminidase B (beta polypeptide)
See related  HGNC:4879|MIM:606873|Ensembl:ENSG00000049860|HPRD:06043|
Locus tag  -
Gene type  protein-coding
Map location  5q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANKFY10.860.89
ZNF5920.850.87
DIP2A0.850.90
MTF10.850.89
ETV30.850.86
ZKSCAN10.850.91
SPAG90.840.88
KSR10.840.88
BICD20.840.89
KIAA03550.840.88
Top 10 negatively co-expressed genes
AF347015.21-0.62-0.73
AF347015.31-0.61-0.68
C1orf54-0.60-0.72
HIGD1B-0.59-0.66
MT-CO2-0.59-0.66
ENHO-0.58-0.65
IFI27-0.58-0.62
FXYD1-0.58-0.63
VAMP5-0.57-0.63
MT3-0.57-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004563beta-N-acetylhexosaminidase activityTAS8663217 
GO:0016798hydrolase activity, acting on glycosyl bondsIEA-
GO:0042803protein homodimerization activityIDA6230359 
GO:0043169cation bindingIEA-
GO:0046982protein heterodimerization activityIDA6230359 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042552myelinationIEAneuron, axon, Brain, oligodendrocyte (GO term level: 13)-
GO:0001501skeletal system developmentIEA-
GO:0008654phospholipid biosynthetic processIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0048477oogenesisIEA-
GO:0008152metabolic processIEA-
GO:0008049male courtship behaviorIEA-
GO:0019953sexual reproductionIEA-
GO:0007626locomotory behaviorIEA-
GO:0007605sensory perception of soundIEA-
GO:0019915sequestering of lipidIEA-
GO:0009313oligosaccharide catabolic processIEA-
GO:0007040lysosome organizationIEA-
GO:0006689ganglioside catabolic processIEA-
GO:0006687glycosphingolipid metabolic processIEA-
GO:0007341penetration of zona pellucidaIEA-
GO:0006874cellular calcium ion homeostasisIEA-
GO:0030203glycosaminoglycan metabolic processIEA-
GO:0050885neuromuscular process controlling balanceIEA-
GO:0031323regulation of cellular metabolic processIEA-
GO:0044267cellular protein metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001669acrosomeIEA-
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HEXBENC-1AShexosaminidase B (beta polypeptide)-HPRD,BioGRID11447134 |12706724 
LGTNHCA56ligatinin vitroBioGRID7299841 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OTHER_GLYCAN_DEGRADATION 1612All SZGR genes in this pathway
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 4430All SZGR genes in this pathway
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 2114All SZGR genes in this pathway
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES 1412All SZGR genes in this pathway
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES 159All SZGR genes in this pathway
KEGG_LYSOSOME 12183All SZGR genes in this pathway
REACTOME_GLYCOSPHINGOLIPID_METABOLISM 3822All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_CS_DS_DEGRADATION 129All SZGR genes in this pathway
REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION 107All SZGR genes in this pathway
REACTOME_HYALURONAN_METABOLISM 147All SZGR genes in this pathway
REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 4933All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM 3021All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_DEGRADATION 117All SZGR genes in this pathway
REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 11169All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_METABOLISM 6940All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN 167100All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP 3024All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP 7851All SZGR genes in this pathway
ROSS_AML_WITH_MLL_FUSIONS 7845All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
APPEL_IMATINIB_RESPONSE 3322All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS 7849All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ZHAN_LATE_DIFFERENTIATION_GENES_UP 3324All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway


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